Gene Symbol | UCP3 |
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Entrez Gene | 7352 |
Alt Symbol | SLC25A9 |
Species | Human |
Gene Type | protein-coding |
Description | uncoupling protein 3 (mitochondrial, proton carrier) |
Other Description | mitochondrial uncoupling protein 3|solute carrier family 25 member 9 |
Swissprots | O60475 Q96HL3 P55916 |
Accessions | AAC18822 AAC51785 AAG02284 EAW74925 EAW74926 EAW74927 P55916 AF001787 AAC51369 AF011449 AAC51767 AK092685 BAG52595 AK290630 BAF83319 AK291889 BAF84578 AK309873 AW295096 BC008392 AAH08392 BU618868 DA876282 U82818 AAC51356 U84763 AAC51367 NM_003356 NP_003347 NM_022803 NP_073714 |
Function | UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance. |
Subcellular Location | Mitochondrion inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
Tissue Specificity | Only in skeletal muscle and heart. Is more expressed in glycolytic than in oxidative skeletal muscles. {ECO:0000269|PubMed:9196039}. |
UCP3 CRISPR/Cas9 KO Plasmid (h) - sc-400866 from Santa Cruz Biotechnology
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UCP3 HDR Plasmid (h) - sc-400866-HDR from Santa Cruz Biotechnology
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UCP3 Double Nickase Plasmid (h) - sc-400866-NIC from Santa Cruz Biotechnology
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UCP3 Double Nickase Plasmid (h2) - sc-400866-NIC-2 from Santa Cruz Biotechnology
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UCP3 CRISPR Activation Plasmid (h) - sc-400866-ACT from Santa Cruz Biotechnology
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UCP3 CRISPR Activation Plasmid (h2) - sc-400866-ACT-2 from Santa Cruz Biotechnology
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UCP3 Lentiviral Activation Particles (h) - sc-400866-LAC from Santa Cruz Biotechnology
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UCP3 Lentiviral Activation Particles (h2) - sc-400866-LAC-2 from Santa Cruz Biotechnology
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UCP3 siRNA (h) - sc-42684 from Santa Cruz Biotechnology
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UCP3 shRNA Plasmid (h) - sc-42684-SH from Santa Cruz Biotechnology
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UCP3 shRNA (h) Lentiviral Particles - sc-42684-V from Santa Cruz Biotechnology
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UCP3 RNAi - H00007352-R02 from Novus Biologicals
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UCP3 RNAi - H00007352-R01 from Novus Biologicals
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MISSION® esiRNA - EHU073081 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2154 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2154 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08114 from Sigma-Aldrich
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UCP3 siRNA (Human) - CRH5027 from Cohesion Biosciences
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UCP3 - MBS8216430 from MyBioSource
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UCP3 CRISPR/Cas9 KO Plasmid (h2) - sc-400866-KO-2 from Santa Cruz Biotechnology
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UCP3 HDR Plasmid (h2) - sc-400866-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human UCP3 (NM_003356.3) - SHH439896 from Creative biogene
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UCP3 shRNA Plasmid (Human) - CHH5027 from Cohesion Biosciences
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UCP3 miRNA 3'UTR clone - MiUTR3H-04621 from Creative biogene
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UCP3 miRNA 3'UTR clone - MiUTR3H-04622 from Creative biogene
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