| Gene Symbol |
GFI1B
|
| Entrez Gene |
8328
|
| Alt Symbol |
BDPLT17
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
growth factor independent 1B transcription repressor
|
| Other Description |
growth factor independent 1B (potential regulator of CDKN1A, translocated in CML)|potential regulator of CDKN1A translocated in CML|zinc finger protein Gfi-1b
|
| Swissprots |
Q6T888 O95270 Q5VTD9 Q5VTD8 Q6FHZ2
|
| Accessions |
CDL93510 EAW88023 EAW88024 EAW88025 Q5VTD9 AF081946 AAD08672 AI097490 AY428733 AAR06639 BC035626 BC043371 AAH43371 BC048254 BX113435 CR536546 CAG38783 XM_006717297 XP_006717360 XM_006717298 XP_006717361 XM_011519068 XP_011517370 XM_011519069 XP_011517371 XM_011519070 XP_011517372 XM_011519071 XP_011517373 XR_929847 NM_001135031 NP_001128503 NM_004188 NP_004179
|
| Function |
Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. Cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1; GFI1B silencing in leukemic cell lines markedly increase apoptosis rate. Inhibits down- regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells. Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription; as GATA1 also mediates erythroid GFI1B transcrip
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:16688220}.
|
| Tissue Specificity |
Expressed in bone marrow and fetal liver, but also detectable in fetal spleen, fetal thymus, and testes. Detected in hematopoietic stem cells, erythroblasts, and megakaryocytes. Overexpressed in bone marrow of patients with erythroleukemia and megakaryocytic leukemia as well as in their corresponding leukemic cell lines, and markedly repressed in severe aplastic anemia (SAA). {ECO:0000269|PubMed:12351384, ECO:0000269|PubMed:17156408, ECO:0000269|PubMed:9878267}.
|