GFI1B

Gene Symbol GFI1B
Entrez Gene 8328
Alt Symbol BDPLT17
Species Human
Gene Type protein-coding
Description growth factor independent 1B transcription repressor
Other Description growth factor independent 1B (potential regulator of CDKN1A, translocated in CML)|potential regulator of CDKN1A translocated in CML|zinc finger protein Gfi-1b
Swissprots Q6T888 O95270 Q5VTD9 Q5VTD8 Q6FHZ2
Accessions CDL93510 EAW88023 EAW88024 EAW88025 Q5VTD9 AF081946 AAD08672 AI097490 AY428733 AAR06639 BC035626 BC043371 AAH43371 BC048254 BX113435 CR536546 CAG38783 XM_006717297 XP_006717360 XM_006717298 XP_006717361 XM_011519068 XP_011517370 XM_011519069 XP_011517371 XM_011519070 XP_011517372 XM_011519071 XP_011517373 XR_929847 NM_001135031 NP_001128503 NM_004188 NP_004179
Function Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. Cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1; GFI1B silencing in leukemic cell lines markedly increase apoptosis rate. Inhibits down- regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells. Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription; as GATA1 also mediates erythroid GFI1B transcrip
Subcellular Location Nucleus {ECO:0000269|PubMed:16688220}.
Tissue Specificity Expressed in bone marrow and fetal liver, but also detectable in fetal spleen, fetal thymus, and testes. Detected in hematopoietic stem cells, erythroblasts, and megakaryocytes. Overexpressed in bone marrow of patients with erythroleukemia and megakaryocytic leukemia as well as in their corresponding leukemic cell lines, and markedly repressed in severe aplastic anemia (SAA). {ECO:0000269|PubMed:12351384, ECO:0000269|PubMed:17156408, ECO:0000269|PubMed:9878267}.

Human GFI1B full length protein - ab152857 from Abcam

Category Protein
Source Wheat germ
Species Human
12.5% SDS-PAGE analysis of ab152857 stained with Coomassie Blue.

Human GFI1B protein fragment - ab152858 from Abcam

Category Protein
Source Wheat germ
Species Human
12.5% SDS-PAGE analysis of ab152858 stained with Coomassie Blue.

Recombinant Human GFI1B Protein - H00008328-P01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

Recombinant Human GFI1B Protein - H00008328-Q01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

GFI1B Blocking Peptide - abx161241 from Abbexa

Category Peptide
Species Human, Mouse, Rat

GFI1B - H00008328-P01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Species Human

GFI1B - H00008328-P01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Species Human

GFI1B - H00008328-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

GFI1B - H00008328-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

GFI1B Blocking Peptide - CBP3740 from Cohesion Biosciences

Category Peptide
Prices $100.00, $300.00
Sizes 1 mg, 5 mg
Species Human, Mouse, Rat

Recombinant Human Zinc finger protein Gfi-1b(GFI1B) - CSB-YP733153HU CSB-EP733153HU CSB-BP733153HU CSB-MP733153HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

Zinc finger protein Gfi-1b (GFI1B) , Recombinant Protein - MBS1358785 from MyBioSource

Category Protein
Prices $1,715.00, $1,715.00, $2,180.00, $2,180.00
Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human

GFI1B-Blocking-Peptide-C-term - BP20437b from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

GFI1B Peptide, Human - M34GP06215H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

GFI1B peptide - orb234615 from Biorbyt

Category Peptide
Prices $247.00, $536.00
Sizes 1 mg, 5 mg
Search more