Gene Symbol | UBQLN4 |
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Entrez Gene | 56893 |
Alt Symbol | A1U, A1Up, C1orf6, CIP75, UBIN |
Species | Human |
Gene Type | protein-coding |
Description | ubiquilin 4 |
Other Description | ataxin-1 interacting ubiquitin-like protein|ataxin-1 ubiquitin-like interacting protein|ataxin-1 ubiquitin-like-interacting protein A1U|connexin43-interacting protein of 75 kDa|ubiquilin-4 |
Swissprots | Q5VYA0 Q9BR98 Q9NRR5 Q5VYA1 A6ND44 B2RAY7 Q9UHX4 |
Accessions | EAW53005 EAW53006 EAW53007 EAW53008 EAW53009 Q9NRR5 AB209566 BAD92803 AF113544 AAF19084 AF188240 AAF80171 AI074831 AK098368 AK302895 BAG64068 AK314413 BAG37034 BC006410 AAH06410 BC018403 AAH18403 BC063841 AAH63841 DC334851 HY061664 XM_005245347 XP_005245404 XM_005245348 XP_005245405 XR_921895 NM_001304342 NP_001291271 NM_020131 NP_064516 |
Function | Plays a role in the regulation of proteasomal protein degradation. Depending on the case, may promote or inhibit proteasomal protein degradation. {ECO:0000269|PubMed:15280365}. |
Subcellular Location | Nucleus. Cytoplasm. Endoplasmic reticulum {ECO:0000305}. Cytoplasm, perinuclear region {ECO:0000250}. Note=Colocalizes with the proteasome, both in nucleus and cytoplasm. May associate with the endoplasmic reticulum. |
Tissue Specificity | Highly expressed in pancreas, kidney, skeletal muscle, heart and throughout the brain, and at lower levels in placenta, lung and liver. {ECO:0000269|PubMed:11001934}. |
Top Pathways | Protein processing in endoplasmic reticulum |
A1Up CRISPR/Cas9 KO Plasmid (h) - sc-407973 from Santa Cruz Biotechnology
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A1Up HDR Plasmid (h) - sc-407973-HDR from Santa Cruz Biotechnology
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A1Up Double Nickase Plasmid (h) - sc-407973-NIC from Santa Cruz Biotechnology
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A1Up Double Nickase Plasmid (h2) - sc-407973-NIC-2 from Santa Cruz Biotechnology
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A1Up CRISPR Activation Plasmid (h) - sc-407973-ACT from Santa Cruz Biotechnology
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A1Up CRISPR Activation Plasmid (h2) - sc-407973-ACT-2 from Santa Cruz Biotechnology
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A1Up Lentiviral Activation Particles (h) - sc-407973-LAC from Santa Cruz Biotechnology
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A1Up Lentiviral Activation Particles (h2) - sc-407973-LAC-2 from Santa Cruz Biotechnology
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A1Up siRNA (h) - sc-78764 from Santa Cruz Biotechnology
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A1Up shRNA Plasmid (h) - sc-78764-SH from Santa Cruz Biotechnology
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A1Up shRNA (h) Lentiviral Particles - sc-78764-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU109861 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22412 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22412 from Sigma-Aldrich
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UBQLN4 siRNA (Human) - CRJ1199 from Cohesion Biosciences
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UBQLN4 - MBS8205141 from MyBioSource
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shRNA set against Human UBQLN4 (NM_020131.3) - SHH439492 from Creative biogene
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shRNA set against Human UBQLN4(NM_020131.3) - SHL112800 from Creative biogene
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UBQLN4 shRNA Plasmid (Human) - CHJ1199 from Cohesion Biosciences
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UBQLN4 miRNA 3'UTR clone - MiUTR3H-07666 from Creative biogene
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