| Gene Symbol | JAK1 |
|---|---|
| Entrez Gene | 3716 |
| Alt Symbol | JAK1A, JAK1B, JTK3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | Janus kinase 1 |
| Other Description | tyrosine-protein kinase JAK1 |
| Swissprots | P23458 Q9UD26 Q59GQ2 |
| Accessions | CBG22571 EAX06547 EAX06548 P23458 AB209057 BAD92294 AB219242 BAE02826 AK128375 AK314257 BC009079 BC023604 AAH23604 BC062431 AAH62431 BC111401 AAI11402 BC132729 AAI32730 BX647675 BX648044 HQ628631 AER93381 M64174 AAA36527 XM_005270841 XP_005270898 XM_006710624 XP_006710687 XM_011541395 XP_011539697 NM_002227 NP_002218 |
| Function | Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor. {ECO:0000269|PubMed:11909529}. |
| Subcellular Location | Endomembrane system; Peripheral membrane protein. Note=Wholly intracellular, possibly membrane associated. |
| Tissue Specificity | Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue. {ECO:0000269|PubMed:7896447}. |
| Top Pathways | Viral carcinogenesis, Pancreatic cancer, Signaling pathways regulating pluripotency of stem cells, Osteoclast differentiation, Epstein-Barr virus infection |