| Gene Symbol |
PPP2CA
|
| Entrez Gene |
5515
|
| Alt Symbol |
PP2Ac, PP2CA, PP2Calpha, RP-C
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein phosphatase 2, catalytic subunit, alpha isozyme
|
| Other Description |
PP2A-alpha|protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform|protein phosphatase 2A catalytic subunit, alpha isoform|replication protein C|serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform|serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
|
| Swissprots |
P67775
|
| Accessions |
AAA36466 EAW62268 EAW62269 P67775 AB451240 BAG70054 AB451365 BAG70179 AK057424 BAG51913 AK097599 BAG53493 AV705728 BC000400 AAH00400 BC002657 AAH02657 BC019275 AAH19275 BC031696 AAH31696 BM786995 CR457417 CAG33698 J03804 AAB38019 X12646 CAA31176 NM_002715 NP_002706
|
| Function |
PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'. {ECO:0000250, ECO:0000269|PubMed:10801873, ECO:0000269|PubMed:22613722, ECO:0000269|PubMed:9920888}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:16541025}. Nucleus {ECO:0000269|PubMed:16541025}. Chromosome, centromere {ECO:0000269|PubMed:16541025}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:16541025}. Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles. Centromeric localization requires the presence of SGOL2 (By similarity). {ECO:0000250}.
|
| Top Pathways |
Sphingolipid signaling pathway, Adrenergic signaling in cardiomyocytes, AMPK signaling pathway, Hippo signaling pathway, TGF-beta signaling pathway
|