PPP2CA

Gene Symbol	PPP2CA
Entrez Gene	5515
Alt Symbol	PP2Ac, PP2CA, PP2Calpha, RP-C
Species	Human
Gene Type	protein-coding
Description	protein phosphatase 2, catalytic subunit, alpha isozyme
Other Description	PP2A-alpha|protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform|protein phosphatase 2A catalytic subunit, alpha isoform|replication protein C|serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform|serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Swissprots	P67775
Accessions	AAA36466 EAW62268 EAW62269 P67775 AB451240 BAG70054 AB451365 BAG70179 AK057424 BAG51913 AK097599 BAG53493 AV705728 BC000400 AAH00400 BC002657 AAH02657 BC019275 AAH19275 BC031696 AAH31696 BM786995 CR457417 CAG33698 J03804 AAB38019 X12646 CAA31176 NM_002715 NP_002706
Function	PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'. {ECO:0000250, ECO:0000269|PubMed:10801873, ECO:0000269|PubMed:22613722, ECO:0000269|PubMed:9920888}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:16541025}. Nucleus {ECO:0000269|PubMed:16541025}. Chromosome, centromere {ECO:0000269|PubMed:16541025}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:16541025}. Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles. Centromeric localization requires the presence of SGOL2 (By similarity). {ECO:0000250}.
Top Pathways	Sphingolipid signaling pathway, Adrenergic signaling in cardiomyocytes, AMPK signaling pathway, Hippo signaling pathway, TGF-beta signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PP2A-alpha full length protein - ab128557 from Abcam Category Protein Prices $239.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Human PP2A alpha + beta peptide - ab57115 from Abcam Category Peptide Species Human

Human PP2A alpha + beta peptide - ab22802 from Abcam Category Peptide Species Human

Human PP2A-alpha full length protein - ab114424 from Abcam Category Protein Source Wheat germ Species Human

PP2Ac / PPP2CA Antibody Blocking Peptide - LS-E20356 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PP2Ac / PPP2CA Antibody Blocking Peptide - LS-E23003 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PP2Ac / PPP2CA Antibody Blocking Peptide - LS-E9594 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PP2A alpha Protein - H00005515-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PP2A alpha Peptide - P3302 from Novus Biologicals Category Peptide Species Human

PP2A-alpha-Antibody-N-term-Blocking-peptide - BP8462a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PPP2CA (phospho-Tyr307) Blocking Peptide - abx063115 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Chicken, Pig, Rabbit, Zebrafish

PPP2CB Peptide - AC21-0088-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

PPP2CA - H00005515-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

PPP2CA - H00005515-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

PPP2CA Control Peptide - AP10276CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 250 µg

PPP2C Peptide - 45-119P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

PPP2CA fusion protein - Ag4294 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human PPP2CA - PPP2CA-27617TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human PPP2CA, His-tagged - PPP2CA-1913H from Creative Biomart Category Protein Source E.coli Species Human

ANTI-PP2Ac - 03AP148 from MP Biomedicals Prices $344.15 Sizes 100 µl

PP2Ac - GLO132 from Nordic BioSite Category Protein

PPP2CA (pY307) Blocking Peptide - CBP1921 from Cohesion Biosciences Category Peptide Prices $150.00, $450.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Bovine, Chicken, Pig, Rabbit, Zebrafish

PP2A-α (T301) Peptide - BS1586P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

p-PP2A-α (Y307) Peptide - BS4867P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform(PPP2CA) - CSB-YP018559HU CSB-EP018559HU CSB-BP018559HU CSB-MP018559HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

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