PPP2CA
| Gene Symbol | PPP2CA |
|---|---|
| Entrez Gene | 5515 |
| Alt Symbol | PP2Ac, PP2CA, PP2Calpha, RP-C |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein phosphatase 2, catalytic subunit, alpha isozyme |
| Other Description | PP2A-alpha|protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform|protein phosphatase 2A catalytic subunit, alpha isoform|replication protein C|serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform|serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform |
| Swissprots | P67775 |
| Accessions | AAA36466 EAW62268 EAW62269 P67775 AB451240 BAG70054 AB451365 BAG70179 AK057424 BAG51913 AK097599 BAG53493 AV705728 BC000400 AAH00400 BC002657 AAH02657 BC019275 AAH19275 BC031696 AAH31696 BM786995 CR457417 CAG33698 J03804 AAB38019 X12646 CAA31176 NM_002715 NP_002706 |
| Function | PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'. {ECO:0000250, ECO:0000269|PubMed:10801873, ECO:0000269|PubMed:22613722, ECO:0000269|PubMed:9920888}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:16541025}. Nucleus {ECO:0000269|PubMed:16541025}. Chromosome, centromere {ECO:0000269|PubMed:16541025}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:16541025}. Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles. Centromeric localization requires the presence of SGOL2 (By similarity). {ECO:0000250}. |
| Top Pathways | Sphingolipid signaling pathway, Adrenergic signaling in cardiomyocytes, AMPK signaling pathway, Hippo signaling pathway, TGF-beta signaling pathway |
PP2A-Cα CRISPR/Cas9 KO Plasmid (h) - sc-400613 from Santa Cruz Biotechnology
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PP2A-Cα HDR Plasmid (h) - sc-400613-HDR from Santa Cruz Biotechnology
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PP2A-Cα Double Nickase Plasmid (h) - sc-400613-NIC from Santa Cruz Biotechnology
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PP2A-Cα Double Nickase Plasmid (h2) - sc-400613-NIC-2 from Santa Cruz Biotechnology
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PP2A-Cα CRISPR Activation Plasmid (h) - sc-400613-ACT from Santa Cruz Biotechnology
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PP2A-Cα CRISPR Activation Plasmid (h2) - sc-400613-ACT-2 from Santa Cruz Biotechnology
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PP2A-Cα Lentiviral Activation Particles (h) - sc-400613-LAC from Santa Cruz Biotechnology
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PP2A-Cα Lentiviral Activation Particles (h2) - sc-400613-LAC-2 from Santa Cruz Biotechnology
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PP2A-Cα siRNA (h) - sc-43509 from Santa Cruz Biotechnology
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PP2A-Cα shRNA Plasmid (h) - sc-43509-SH from Santa Cruz Biotechnology
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PP2A-Cα shRNA (h) Lentiviral Particles - sc-43509-V from Santa Cruz Biotechnology
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PP2A alpha RNAi - H00005515-R02 from Novus Biologicals
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MISSION® esiRNA - EHU155171 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0601 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0603 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0602 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1053 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1053 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08963 from Sigma-Aldrich
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PPP2CA siRNA (Human) - CRH3695 from Cohesion Biosciences
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PP2A-Cα CRISPR/Cas9 KO Plasmid (h2) - sc-400613-KO-2 from Santa Cruz Biotechnology
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PP2A-Cα HDR Plasmid (h2) - sc-400613-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human PPP2CA (NM_002715.2) - SHH381336 from Creative biogene
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shRNA set against Human PPP2CA(NM_002715.2) - SHR134212 from Creative biogene
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PPP2CA shRNA Plasmid (Human) - CHH3695 from Cohesion Biosciences
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