| Gene Symbol |
LAGE3
|
| Entrez Gene |
8270
|
| Alt Symbol |
CVG5, DXS9879E, DXS9951E, ESO3, ITBA2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
L antigen family, member 3
|
| Other Description |
EKC/KEOPS complex subunit LAGE3|protein ESO-3
|
| Swissprots |
Q5HY39 Q8IZ78 Q14657
|
| Accessions |
EAW72701 Q14657 BC015744 AAH15744 BC019012 BC062330 AAH62330 BQ649305 EU832327 ACE87584 EU832412 ACE86897 HQ448067 ADQ32548 X92896 CAA63489 NM_006014 NP_006005
|
| Function |
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. LAGE3 functions as a dimerization module for the complex (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:22912744}.
|
| Tissue Specificity |
Ubiquitous. {ECO:0000269|PubMed:12384295, ECO:0000269|PubMed:8786131}.
|