| Gene Symbol |
JARID2
|
| Entrez Gene |
3720
|
| Alt Symbol |
JMJ
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
jumonji, AT rich interactive domain 2
|
| Other Description |
jumonji homolog|jumonji-like protein|jumonji/ARID domain-containing protein 2|protein Jumonji
|
| Swissprots |
B7Z8L0 B7Z5S5 Q5U5L5 A8K9Z6 Q92833 Q86X63
|
| Accessions |
EAW55357 EAW55358 Q92833 AF401209 AAL02168 AK126552 AK292861 BAF85550 AK299349 BAH13011 AK302624 BAH13765 AK303610 BAH13996 BC046184 AAH46184 BC046246 AAH46246 CA435807 U57592 AAC50822 XM_005249089 XP_005249146 XM_011514578 XP_011512880 XM_011514579 XP_011512881 XM_011514580 XP_011512882 XM_011514581 XP_011512883 XM_011514582 XP_011512884 XM_011514583 XP_011512885 XM_011514584 XP_011512886 NM_001267040 NP_001253969 NM_004973 NP_004964
|
| Function |
Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00355, ECO:0000255|PROSITE-ProRule:PRU00537, ECO:0000269|PubMed:20075857}. Note=Colocalizes with the PRC2 complex on chromatin.
|
| Tissue Specificity |
During embryogenesis, predominantly expressed in neurons and particularly in dorsal root ganglion cells.
|
| Top Pathways |
Signaling pathways regulating pluripotency of stem cells
|