JARID2

Gene Symbol	JARID2
Entrez Gene	3720
Alt Symbol	JMJ
Species	Human
Gene Type	protein-coding
Description	jumonji, AT rich interactive domain 2
Other Description	jumonji homolog|jumonji-like protein|jumonji/ARID domain-containing protein 2|protein Jumonji
Swissprots	B7Z8L0 B7Z5S5 Q5U5L5 A8K9Z6 Q92833 Q86X63
Accessions	EAW55357 EAW55358 Q92833 AF401209 AAL02168 AK126552 AK292861 BAF85550 AK299349 BAH13011 AK302624 BAH13765 AK303610 BAH13996 BC046184 AAH46184 BC046246 AAH46246 CA435807 U57592 AAC50822 XM_005249089 XP_005249146 XM_011514578 XP_011512880 XM_011514579 XP_011512881 XM_011514580 XP_011512882 XM_011514581 XP_011512883 XM_011514582 XP_011512884 XM_011514583 XP_011512885 XM_011514584 XP_011512886 NM_001267040 NP_001253969 NM_004973 NP_004964
Function	Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00355, ECO:0000255|PROSITE-ProRule:PRU00537, ECO:0000269|PubMed:20075857}. Note=Colocalizes with the PRC2 complex on chromatin.
Tissue Specificity	During embryogenesis, predominantly expressed in neurons and particularly in dorsal root ganglion cells.
Top Pathways	Signaling pathways regulating pluripotency of stem cells

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

JARID2 (D6M9X) Rabbit mAb - 13594 from Cell Signaling Technology Prices $99.00, $246.00 Sizes 20 µl (2 western blots), 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D6M9X

Jumonji (C-17) - sc-47604 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Jumonji (K-17) - sc-47605 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-Jarid2 antibody - ab184152 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Jarid2 antibody - ab183871 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Jarid2 antibody - ab157000 from Abcam Host Rabbit Clonality Polyclonal

Anti-Jarid2 antibody - ab48137 from Abcam Prices $382.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Jarid2 antibody [EPR6357(2)] - ab192252 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR6357(2)

Anti-Jarid2 antibody - ChIP Grade - ab178561 from Abcam Prices $378.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-Jarid2 antibody - ChIP Grade - ab93288 from Abcam Prices $378.00 Sizes 50 µl Host Mouse Clonality Polyclonal

Anti-JARID2 / JMJ Antibody (aa1-100) - LS-C49010 from LifeSpan Bioscience Prices $335.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-JARID2 / JMJ Antibody (aa293-307) - LS-C108913 from LifeSpan Bioscience Prices $335.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-JARID2 / JMJ Antibody (aa1-159) - LS-C130310 from LifeSpan Bioscience Prices $605.00 Sizes 100 µg Host Sheep Clonality Polyclonal

Anti-JARID2 / JMJ Antibody (N-Terminus, Biotin) - LS-C140928 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-JARID2 / JMJ Antibody (N-Terminus, DY488) - LS-C140930 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-JARID2 / JMJ Antibody (N-Terminus, DY650) - LS-C140929 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-JARID2 / JMJ Antibody (N-Terminus, DY550) - LS-C140932 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-JARID2 / JMJ Antibody (N-Terminus, HRP) - LS-C140931 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-JARID2 / JMJ Antibody (N-Terminus) - LS-C347789 from LifeSpan Bioscience Prices $345.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-JARID2 / JMJ Antibody (aa215-264) - LS-C107878 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-JARID2 / JMJ Antibody (aa201-250) - LS-C116081 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Jumonji/JARID2 Antibody - NB100-2214 from Novus Biologicals Prices $129.00, $299.00 Sizes 25 µl, 100 µl Host Rabbit Clonality Polyclonal

Jumonji/JARID2 Antibody - AF6090 from Novus Biologicals Prices $99.00, $359.00 Sizes 25 µg, 100 µg Host Sheep Clonality Polyclonal

Jumonji/JARID2 Antibody (674702) - MAB6090 from Novus Biologicals Prices $99.00, $249.00 Sizes 25 µg, 100 µg Host Mouse Clonality Monoclonal Clone 674702

Jumonji/JARID2 Antibody - H00003720-A01 from Novus Biologicals Prices $269.00 Sizes 50 µl Host Mouse Clonality Polyclonal

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