JARID2

Gene Symbol	JARID2
Entrez Gene	3720
Alt Symbol	JMJ
Species	Human
Gene Type	protein-coding
Description	jumonji, AT rich interactive domain 2
Other Description	jumonji homolog|jumonji-like protein|jumonji/ARID domain-containing protein 2|protein Jumonji
Swissprots	B7Z8L0 B7Z5S5 Q5U5L5 A8K9Z6 Q92833 Q86X63
Accessions	EAW55357 EAW55358 Q92833 AF401209 AAL02168 AK126552 AK292861 BAF85550 AK299349 BAH13011 AK302624 BAH13765 AK303610 BAH13996 BC046184 AAH46184 BC046246 AAH46246 CA435807 U57592 AAC50822 XM_005249089 XP_005249146 XM_011514578 XP_011512880 XM_011514579 XP_011512881 XM_011514580 XP_011512882 XM_011514581 XP_011512883 XM_011514582 XP_011512884 XM_011514583 XP_011512885 XM_011514584 XP_011512886 NM_001267040 NP_001253969 NM_004973 NP_004964
Function	Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00355, ECO:0000255|PROSITE-ProRule:PRU00537, ECO:0000269|PubMed:20075857}. Note=Colocalizes with the PRC2 complex on chromatin.
Tissue Specificity	During embryogenesis, predominantly expressed in neurons and particularly in dorsal root ganglion cells.
Top Pathways	Signaling pathways regulating pluripotency of stem cells

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Jarid2 protein fragment - ab112313 from Abcam Category Protein Source Wheat germ Species Human

JARID2 / JMJ Antibody Blocking Peptide - LS-E27202 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

JARID2 / JMJ Antibody Blocking Peptide - LS-E21530 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

JARID2 / JMJ Antibody Blocking Peptide - LS-E13374 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Jumonji/JARID2 Blocking Peptide - NB100-2214PEP from Novus Biologicals Category Peptide Prices $69.00 Sizes 50 µg Species Human

Recombinant Human Jumonji/JARID2 Protein - H00003720-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

JARID2 blocking peptide - GTX88273-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Pig, Rat, Bovine

JARID2 Immunizing peptide - orb15240 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

JARID2 Blocking Peptide - 33R-9106 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

JARID2 Peptide - AC21-2022-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

JARID2 / Jumonji - H00003720-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

JARID2 / Jumonji - H00003720-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

JARID2 Peptide - 42-244P from ProSci Category Peptide Prices $175.00 Sizes 100 µg

JARID2 fusion protein - ag15567 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

JARID2 fusion protein - ag16618 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

JARID2 fusion protein - Ag24536 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET30a Species Human

Recombinant Human JARID2 - JARID2-27632TH from Creative Biomart Category Protein Source Wheat germ Species Human

Recombinant Human Protein Jumonji(JARID2) ,partial - CSB-YP852915HU CSB-EP852915HU CSB-BP852915HU CSB-MP852915HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

JARID2, Peptide - MBS425426 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog, Pig, Bovine

JARID2 Peptide, Human - M34GP07857H from Creative Peptides Category Peptide Source Synthetic. Species Human

Jumonji/JARID2 Recombinant Protein Antigen - NBP2-57019PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Protein Jumonji (JARID2), partial, Recombinant Protein - MBS1315915 from MyBioSource Category Protein Prices $1,315.00, $1,315.00, $1,545.00, $1,545.00, $2,110.00, $2,110.00, $2,550.00, $2,550.00, $2,585.00, $4,165.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 50 µg (Mammalian-Cell), 500 µg (Yeast), 1 mg (E-Coli), 100 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast), 500 µg (Baculovirus), 1 mg (Baculovirus) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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