Gene Symbol | IPO13 |
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Entrez Gene | 9670 |
Alt Symbol | IMP13, KAP13, LGL2, RANBP13 |
Species | Human |
Gene Type | protein-coding |
Description | importin 13 |
Other Description | Ran binding protein 13|importin-13|karyopherin 13|karyopherin-13|late gestation lung 2|ran-binding protein 13 |
Swissprots | Q96HS3 O94829 Q9H8N3 Q9UFR1 Q7LC04 Q5T4X3 D3DPY4 |
Accessions | EAX07072 EAX07073 O94829 AB018267 BAA34444 AF267987 AAF73471 AK023441 BAB14575 AK091565 BAG52382 AK290173 BAF82862 AL117501 CAB55966 BC002608 AAH02608 BC008194 AAH08194 BX116797 JF432433 ADZ15650 XM_011542461 XP_011540763 NM_014652 NP_055467 |
Function | Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the l |
Subcellular Location | Cytoplasm. Nucleus. |
Tissue Specificity | Expressed in fetal brain, heart, intestine and kidney. {ECO:0000269|PubMed:10745026}. |
karyopherin 13 (A-9) - sc-271560 from Santa Cruz Biotechnology
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karyopherin 13 (B-8) - sc-271751 from Santa Cruz Biotechnology
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karyopherin 13 (D-3) - sc-271218 from Santa Cruz Biotechnology
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karyopherin 13 (D-8) - sc-393661 from Santa Cruz Biotechnology
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karyopherin 13 (H-300) - sc-367820 from Santa Cruz Biotechnology
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karyopherin 13 (V-20) - sc-68097 from Santa Cruz Biotechnology
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Anti-Importin 13 antibody - ab118417 from Abcam
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Anti-IPO13 / LGL2 Antibody (aa901-963) - LS-C185927 from LifeSpan Bioscience
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Anti-IPO13 / LGL2 Antibody - LS-C333241 from LifeSpan Bioscience
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Anti-IPO13 / LGL2 Antibody (aa222-420) - LS-C178635 from LifeSpan Bioscience
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Importin-13 Antibody - NBP1-31508 from Novus Biologicals
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Importin-13 Antibody - NBP2-14994 from Novus Biologicals
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Anti-IPO13 (651-665) antibody produced in rabbit - SAB1100666 from Sigma-Aldrich
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Anti-IPO13 (N-terminal) antibody produced in rabbit - SAB2700514 from Sigma-Aldrich
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Importin 13 antibody [C3], C-term - GTX107982 from GeneTex
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Importin 13 antibody [N1N2], N-term - GTX115274 from GeneTex
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IPO13 antibody - orb78012 from Biorbyt
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IPO13 antibody - 70R-17999 from Fitzgerald
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Anti -IPO13 (Importin 13, LGL2, IMP13, KAP13, RANBP13) - 211526 from USBiological Life Science
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IPO13 Polyclonal Antibody - A4331 from ABclonal
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IPO13 antibody- C terminal region (OAGA00622) - OAGA00622 from Aviva Systems Biology
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Importin 13 antibody - orb69713 from Biorbyt
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Importin 13 antibody - 70R-13130 from Fitzgerald
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IPO13 Antibody - abx036280 from Abbexa
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IPO13 Antibody - abx003222 from Abbexa
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