IPO13
| Gene Symbol | IPO13 |
|---|---|
| Entrez Gene | 9670 |
| Alt Symbol | IMP13, KAP13, LGL2, RANBP13 |
| Species | Human |
| Gene Type | protein-coding |
| Description | importin 13 |
| Other Description | Ran binding protein 13|importin-13|karyopherin 13|karyopherin-13|late gestation lung 2|ran-binding protein 13 |
| Swissprots | Q96HS3 O94829 Q9H8N3 Q9UFR1 Q7LC04 Q5T4X3 D3DPY4 |
| Accessions | EAX07072 EAX07073 O94829 AB018267 BAA34444 AF267987 AAF73471 AK023441 BAB14575 AK091565 BAG52382 AK290173 BAF82862 AL117501 CAB55966 BC002608 AAH02608 BC008194 AAH08194 BX116797 JF432433 ADZ15650 XM_011542461 XP_011540763 NM_014652 NP_055467 |
| Function | Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the l |
| Subcellular Location | Cytoplasm. Nucleus. |
| Tissue Specificity | Expressed in fetal brain, heart, intestine and kidney. {ECO:0000269|PubMed:10745026}. |
karyopherin 13 CRISPR/Cas9 KO Plasmid (h) - sc-404551 from Santa Cruz Biotechnology
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karyopherin 13 HDR Plasmid (h) - sc-404551-HDR from Santa Cruz Biotechnology
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karyopherin 13 Double Nickase Plasmid (h) - sc-404551-NIC from Santa Cruz Biotechnology
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karyopherin 13 Double Nickase Plasmid (h2) - sc-404551-NIC-2 from Santa Cruz Biotechnology
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karyopherin 13 CRISPR Activation Plasmid (h) - sc-404551-ACT from Santa Cruz Biotechnology
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karyopherin 13 CRISPR Activation Plasmid (h2) - sc-404551-ACT-2 from Santa Cruz Biotechnology
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karyopherin 13 Lentiviral Activation Particles (h) - sc-404551-LAC from Santa Cruz Biotechnology
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karyopherin 13 Lentiviral Activation Particles (h2) - sc-404551-LAC-2 from Santa Cruz Biotechnology
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karyopherin 13 siRNA (h) - sc-62521 from Santa Cruz Biotechnology
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karyopherin 13 shRNA Plasmid (h) - sc-62521-SH from Santa Cruz Biotechnology
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karyopherin 13 shRNA (h) Lentiviral Particles - sc-62521-V from Santa Cruz Biotechnology
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Importin-13 RNAi - H00009670-R01 from Novus Biologicals
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MISSION® esiRNA - EHU030291 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10730 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10730 from Sigma-Aldrich
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IPO13 siRNA (Human) - CRH6444 from Cohesion Biosciences
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IPO13 - MBS8225107 from MyBioSource
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karyopherin 13 CRISPR/Cas9 KO Plasmid (h2) - sc-404551-KO-2 from Santa Cruz Biotechnology
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karyopherin 13 HDR Plasmid (h2) - sc-404551-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human IPO13 (NM_014652.3) - SHH320153 from Creative biogene
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Human IPO13 siRNA - orb266946 from Biorbyt
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IPO13 shRNA Plasmid (Human) - CHH6444 from Cohesion Biosciences
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IPO13 miRNA 3'UTR clone - MiUTR3H-11221 from Creative biogene
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