Gene Symbol | POLR2C |
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Entrez Gene | 5432 |
Alt Symbol | RPB3, RPB31, hRPB33, hsRPB3 |
Species | Human |
Gene Type | protein-coding |
Description | polymerase (RNA) II (DNA directed) polypeptide C, 33kDa |
Other Description | DNA-directed RNA polymerase II 33 kDa polypeptide|DNA-directed RNA polymerase II subunit C|DNA-directed RNA polymerase II subunit RPB3|RNA polymerase II subunit 3|RNA polymerase II subunit B3|RPB33 |
Swissprots | O15161 P19387 |
Accessions | AAC24309 EAW82926 EAW82927 EAW82929 EAW82930 P19387 AF008443 AAC14355 AJ224143 CAA11842 AJ224144 CAA11843 AK293112 BAF85801 AK295582 BAH12113 AK300124 BAH13217 BC000409 AAH00409 BC003159 AAH03159 BC028157 AAH28157 BI458170 CR542041 CAG46838 DQ891411 ABM82337 DQ894586 ABM85512 EU176305 ABW03756 J05448 AAA36586 XM_011523111 XP_011521413 NM_032940 NP_116558 NM_002694 |
Function | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:9852112}. |
Top Pathways | Huntington's disease, Epstein-Barr virus infection, Purine metabolism, RNA polymerase, Pyrimidine metabolism |
Anti-POLR2C antibody - ab186867 from Abcam
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Anti-POLR2C antibody - ab14252 from Abcam
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Anti-POLR2C antibody - ab127037 from Abcam
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Anti-POLR2C antibody - ab135210 from Abcam
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Anti-POLR2C antibody [EPR13294(B)] - ab182150 from Abcam
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Anti-POLR2C antibody [EPR13300(B)] - C-terminal - ab181193 from Abcam
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Anti-POLR2C Antibody - LS-C341346 from LifeSpan Bioscience
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Anti-POLR2C Antibody (aa186-235) - LS-C187210 from LifeSpan Bioscience
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Anti-POLR2C Antibody (clone 1C11) - LS-C197943 from LifeSpan Bioscience
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Anti-POLR2C Antibody (aa225-275) - LS-C290426 from LifeSpan Bioscience
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Anti-POLR2C Antibody (aa38-238) - LS-C179115 from LifeSpan Bioscience
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Anti-POLR2C Antibody (aa200-228) - LS-C344181 from LifeSpan Bioscience
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Anti-POLR2C Antibody - LS-C331689 from LifeSpan Bioscience
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POLR2C Antibody - NBP1-80817 from Novus Biologicals
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POLR2C Antibody - NBP1-80818 from Novus Biologicals
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POLR2C Antibody - NBP2-19885 from Novus Biologicals
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POLR2C Antibody - NBP2-32319 from Novus Biologicals
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POLR2C Antibody (1C11) - H00005432-M01 from Novus Biologicals
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Anti-POLR2C antibody produced in rabbit - HPA040919 from Sigma-Aldrich
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Monoclonal Anti-POLR2C antibody produced in mouse - SAB1401292 from Sigma-Aldrich
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Anti-POLR2C (211-225) antibody produced in rabbit - SAB1100540 from Sigma-Aldrich
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POLR2C Antibody - C-terminal region (ARP57690_P050) - ARP57690_P050 from Aviva Systems Biology
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POLR2C-Antibody-C-term - AP20520b from Abgent, a WuXi AppTec company
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POLR2C Antibody - C-terminal region (OAAB18043) - OAAB18043 from Aviva Systems Biology
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POLR2C antibody - orb78448 from Biorbyt
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