Gene Symbol | POLR2C |
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Entrez Gene | 5432 |
Alt Symbol | RPB3, RPB31, hRPB33, hsRPB3 |
Species | Human |
Gene Type | protein-coding |
Description | polymerase (RNA) II (DNA directed) polypeptide C, 33kDa |
Other Description | DNA-directed RNA polymerase II 33 kDa polypeptide|DNA-directed RNA polymerase II subunit C|DNA-directed RNA polymerase II subunit RPB3|RNA polymerase II subunit 3|RNA polymerase II subunit B3|RPB33 |
Swissprots | O15161 P19387 |
Accessions | AAC24309 EAW82926 EAW82927 EAW82929 EAW82930 P19387 AF008443 AAC14355 AJ224143 CAA11842 AJ224144 CAA11843 AK293112 BAF85801 AK295582 BAH12113 AK300124 BAH13217 BC000409 AAH00409 BC003159 AAH03159 BC028157 AAH28157 BI458170 CR542041 CAG46838 DQ891411 ABM82337 DQ894586 ABM85512 EU176305 ABW03756 J05448 AAA36586 XM_011523111 XP_011521413 NM_032940 NP_116558 NM_002694 |
Function | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:9852112}. |
Top Pathways | Huntington's disease, Epstein-Barr virus infection, Purine metabolism, RNA polymerase, Pyrimidine metabolism |
Human POLR2C full length protein - ab181910 from Abcam
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POLR2C Antibody Blocking Peptide - LS-E21067 from LifeSpan Bioscience
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POLR2C Recombinant Protein - H00005432-P01 from Novus Biologicals
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POLR2C Recombinant Protein - H00005432-P02 from Novus Biologicals
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POLR2C protein (His tag) - 80R-3857 from Fitzgerald
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POLR2C (1-275, His-tag) - AR51544PU-N from Acris Antibodies
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POLR2C (1-275, His-tag) - AR51544PU-S from Acris Antibodies
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POLR2C - H00005432-P01-02 from Acris Antibodies
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POLR2C - H00005432-P02 from Acris Antibodies
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POLR2C - H00005432-P02-02 from Acris Antibodies
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POLR2C, 1-275aa, Human, His tag, E.coli - 01-P2724 from ARP American Research Products
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POLR2C fusion protein - Ag4228 from Proteintech Group
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Recombinant Human POLR2C, T7-tagged - POLR2C-3055H from Creative Biomart
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Recombinant Human POLR2C, His-tagged - POLR2C-8462H from Creative Biomart
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Recombinant Human POLR2C, His-tagged - POLR2C-231H from Creative Biomart
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Recombinant Human POLR2C, His-tagged - POLR2C-1841H from Creative Biomart
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Recombinant Human DNA-directed RNA polymerase II subunit RPB3(POLR2C) - CSB-YP018329HU CSB-EP018329HU CSB-BP018329HU CSB-MP018329HU from Cusabio
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POLR2C, 1-275aa, Human, His tag, E.coli - ATGP2724 from ATGen
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POLR2C, Recombinant Protein - MBS205724 from MyBioSource
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Recombinant Human RNA Polymerase II p33 subunit GST - CSI13948 from Cell Science
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Recombinant Human RNA Polymerase II p33 subunit His - CSI13890 from Cell Science
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Human POLR2C protein - orb260024 from Biorbyt
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POLR2C Recombinant Protein Antigen - NBP1-80818PEP from Novus Biologicals
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POLR2C Recombinant Protein Antigen - NBP1-80817PEP from Novus Biologicals
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POLR2C-Blocking-Peptide-C-term - BP20520b from Abgent, a WuXi AppTec company
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