| Gene Symbol |
POLR2C
|
| Entrez Gene |
5432
|
| Alt Symbol |
RPB3, RPB31, hRPB33, hsRPB3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
polymerase (RNA) II (DNA directed) polypeptide C, 33kDa
|
| Other Description |
DNA-directed RNA polymerase II 33 kDa polypeptide|DNA-directed RNA polymerase II subunit C|DNA-directed RNA polymerase II subunit RPB3|RNA polymerase II subunit 3|RNA polymerase II subunit B3|RPB33
|
| Swissprots |
O15161 P19387
|
| Accessions |
AAC24309 EAW82926 EAW82927 EAW82929 EAW82930 P19387 AF008443 AAC14355 AJ224143 CAA11842 AJ224144 CAA11843 AK293112 BAF85801 AK295582 BAH12113 AK300124 BAH13217 BC000409 AAH00409 BC003159 AAH03159 BC028157 AAH28157 BI458170 CR542041 CAG46838 DQ891411 ABM82337 DQ894586 ABM85512 EU176305 ABW03756 J05448 AAA36586 XM_011523111 XP_011521413 NM_032940 NP_116558 NM_002694
|
| Function |
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:9852112}.
|
| Top Pathways |
Huntington's disease, Epstein-Barr virus infection, Purine metabolism, RNA polymerase, Pyrimidine metabolism
|
![Western Blot: POLR2C Overexpression Lysate (Adult Normal) [NBL1-14580] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for POLR2C.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7901_POLR2C%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14580-img0002.jpg)