| Gene Symbol |
KRT74
|
| Entrez Gene |
121391
|
| Alt Symbol |
ADWH, HTSS2, HYPT3, K6IRS4, KRT5C, KRT6IRS4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
keratin 74, type II
|
| Other Description |
CK-74|K5C|K74|cytokeratin-74|keratin 5c|keratin 6 irs4|keratin, type II cytoskeletal 74|keratin-5c|keratin-74|type II inner root sheath-specific keratin-K6irs4|type-II keratin Kb37
|
| Swissprots |
B5MD61 Q7RTS7 Q86Y45
|
| Accessions |
DAA00404 EAW96637 Q7RTS7 AF086480 AI092341 AJ508777 CAD48514 BC160050 AAI60050 XM_011537902 XP_011536204 NM_175053 NP_778223
|
| Function |
Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable). {ECO:0000305}.
|
| Tissue Specificity |
Highly expressed in hair follicles from scalp. In hair, it is specifically present in the inner root sheath (IRS) of the hair follicle. Present in the IRS Huxley layer, but not in Henle layer or cuticle of the IRS. In the IRS Huxley layer, it is expressed in specialized Huxley cells, termed 'Fluegelzellen, along the area of differentiated Henle cells (at protein level). {ECO:0000269|PubMed:12648212, ECO:0000269|PubMed:16874310, ECO:0000269|PubMed:24714551}.
|