Gene Symbol | NDFIP2 |
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Entrez Gene | 54602 |
Alt Symbol | N4WBP5A |
Species | Human |
Gene Type | protein-coding |
Description | Nedd4 family interacting protein 2 |
Other Description | MAPK-activating protein PM04 PM05 PM06 PM07|NEDD4 WW domain-binding protein 5A|NEDD4 family-interacting protein 2|NF-kappa-B-activating protein 413|putative MAPK-activating protein PM04/PM05/PM06/PM07|putative NF-kappa-B-activating protein 413 |
Swissprots | Q9ULQ5 Q7Z2H3 Q7Z428 Q9NV92 Q8TAR3 |
Accessions | EAW80599 Q9NV92 AB032991 BAA86479 AB097019 BAC77372 AB097028 BAC77381 AB097029 BAC77382 AB097030 BAC77383 AB097031 BAC77384 AK001723 BAA91863 AK098708 AK294839 BAG57947 AK297197 BAG59684 BC021988 AAH21988 BC026126 AAH26126 BM976935 DC320871 XM_006719840 XP_006719903 XR_245389 NM_001161407 NP_001154879 NM_019080 NP_061953 |
Function | Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. May modulate EGFR signaling. {ECO:0000269|PubMed:12761501, ECO:0000269|PubMed:19343052, ECO:0000269|PubMed:20534535}. |
Subcellular Location | Endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane. Endosome, multivesicular body membrane. |
Tissue Specificity | Expressed in brain, lung, heart, skeletal muscle, kidney, liver and placenta. {ECO:0000269|PubMed:12796489}. |
Ndfip2 (E-4) - sc-376259 from Santa Cruz Biotechnology
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Ndfip2 (P-14) - sc-84526 from Santa Cruz Biotechnology
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Anti-NDFIP2 antibody - ab67912 from Abcam
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Anti-NDFIP2 antibody - ab105319 from Abcam
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Anti-NDFIP2 Antibody (aa251-300) - LS-C116369 from LifeSpan Bioscience
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Anti-NDFIP2 Antibody (aa152-201) - LS-C135227 from LifeSpan Bioscience
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NDFIP2 Antibody - NBP1-56990 from Novus Biologicals
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NDFIP2 Antibody - NBP1-81436 from Novus Biologicals
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NDFIP2 Antibody - H00054602-B02P from Novus Biologicals
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NDFIP2 Antibody (2C7) - H00054602-M06 from Novus Biologicals
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Anti-NDFIP2 antibody produced in mouse - SAB1407558 from Sigma-Aldrich
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Anti-NDFIP2 antibody produced in rabbit - HPA009160 from Sigma-Aldrich
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Anti-NDFIP2 antibody produced in rabbit - SAB2105726 from Sigma-Aldrich
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Monoclonal Anti-NDFIP2 antibody produced in mouse - SAB1401729 from Sigma-Aldrich
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NDFIP2 antibody - middle region (ARP49441_P050) - ARP49441_P050 from Aviva Systems Biology
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NDFIP2 antibody (FITC) - orb222320 from Biorbyt
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NDFIP2 antibody - 70R-4486 from Fitzgerald
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NDFIP2 antibody - H00054602-B02P from Acris Antibodies
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NDFIP2 antibody - H00054602-M06 from Acris Antibodies
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NDFIP2 Antibody - GWB-MR506B from Genway Biotech
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NDFIP2, Monoclonal Antibody - MBS6012085 from MyBioSource
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Anti-NDFIP2 monoclonal antibody - DCABH-16178 from Creative Diagnostics
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NDFIP2, Polyclonal Antibody - MBS646335 from MyBioSource
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Anti-Nedd4 family interacting protein 2 - 08A054602 from MP Biomedicals
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NDFIP2-antibody-middle-region-AI13026 - AI13026 from Abgent, a WuXi AppTec company
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