| Gene Symbol |
NDFIP2
|
| Entrez Gene |
54602
|
| Alt Symbol |
N4WBP5A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Nedd4 family interacting protein 2
|
| Other Description |
MAPK-activating protein PM04 PM05 PM06 PM07|NEDD4 WW domain-binding protein 5A|NEDD4 family-interacting protein 2|NF-kappa-B-activating protein 413|putative MAPK-activating protein PM04/PM05/PM06/PM07|putative NF-kappa-B-activating protein 413
|
| Swissprots |
Q9ULQ5 Q7Z2H3 Q7Z428 Q9NV92 Q8TAR3
|
| Accessions |
EAW80599 Q9NV92 AB032991 BAA86479 AB097019 BAC77372 AB097028 BAC77381 AB097029 BAC77382 AB097030 BAC77383 AB097031 BAC77384 AK001723 BAA91863 AK098708 AK294839 BAG57947 AK297197 BAG59684 BC021988 AAH21988 BC026126 AAH26126 BM976935 DC320871 XM_006719840 XP_006719903 XR_245389 NM_001161407 NP_001154879 NM_019080 NP_061953
|
| Function |
Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. May modulate EGFR signaling. {ECO:0000269|PubMed:12761501, ECO:0000269|PubMed:19343052, ECO:0000269|PubMed:20534535}.
|
| Subcellular Location |
Endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane. Endosome, multivesicular body membrane.
|
| Tissue Specificity |
Expressed in brain, lung, heart, skeletal muscle, kidney, liver and placenta. {ECO:0000269|PubMed:12796489}.
|