Gene Symbol | NDFIP2 |
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Entrez Gene | 54602 |
Alt Symbol | N4WBP5A |
Species | Human |
Gene Type | protein-coding |
Description | Nedd4 family interacting protein 2 |
Other Description | MAPK-activating protein PM04 PM05 PM06 PM07|NEDD4 WW domain-binding protein 5A|NEDD4 family-interacting protein 2|NF-kappa-B-activating protein 413|putative MAPK-activating protein PM04/PM05/PM06/PM07|putative NF-kappa-B-activating protein 413 |
Swissprots | Q9ULQ5 Q7Z2H3 Q7Z428 Q9NV92 Q8TAR3 |
Accessions | EAW80599 Q9NV92 AB032991 BAA86479 AB097019 BAC77372 AB097028 BAC77381 AB097029 BAC77382 AB097030 BAC77383 AB097031 BAC77384 AK001723 BAA91863 AK098708 AK294839 BAG57947 AK297197 BAG59684 BC021988 AAH21988 BC026126 AAH26126 BM976935 DC320871 XM_006719840 XP_006719903 XR_245389 NM_001161407 NP_001154879 NM_019080 NP_061953 |
Function | Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. May modulate EGFR signaling. {ECO:0000269|PubMed:12761501, ECO:0000269|PubMed:19343052, ECO:0000269|PubMed:20534535}. |
Subcellular Location | Endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane. Endosome, multivesicular body membrane. |
Tissue Specificity | Expressed in brain, lung, heart, skeletal muscle, kidney, liver and placenta. {ECO:0000269|PubMed:12796489}. |
Ndfip2 CRISPR/Cas9 KO Plasmid (h) - sc-405125 from Santa Cruz Biotechnology
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Ndfip2 HDR Plasmid (h) - sc-405125-HDR from Santa Cruz Biotechnology
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Ndfip2 Double Nickase Plasmid (h) - sc-405125-NIC from Santa Cruz Biotechnology
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Ndfip2 Double Nickase Plasmid (h2) - sc-405125-NIC-2 from Santa Cruz Biotechnology
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Ndfip2 CRISPR Activation Plasmid (h) - sc-405125-ACT from Santa Cruz Biotechnology
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Ndfip2 CRISPR Activation Plasmid (h2) - sc-405125-ACT-2 from Santa Cruz Biotechnology
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Ndfip2 Lentiviral Activation Particles (h) - sc-405125-LAC from Santa Cruz Biotechnology
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Ndfip2 Lentiviral Activation Particles (h2) - sc-405125-LAC-2 from Santa Cruz Biotechnology
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Ndfip2 siRNA (h) - sc-75888 from Santa Cruz Biotechnology
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Ndfip2 shRNA Plasmid (h) - sc-75888-SH from Santa Cruz Biotechnology
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Ndfip2 shRNA (h) Lentiviral Particles - sc-75888-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU036541 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15121 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15121 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09821 from Sigma-Aldrich
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NDFIP2 siRNA (Human) - CRJ0152 from Cohesion Biosciences
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shRNA set against Human NDFIP2 (NM_019080.2) - SHH350300 from Creative biogene
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Human NDFIP2 siRNA - orb270653 from Biorbyt
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NDFIP2 shRNA Plasmid (Human) - CHJ0152 from Cohesion Biosciences
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