Gene Symbol | Bcat1 |
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Entrez Gene | 12035 |
Alt Symbol | BCATc, Eca39 |
Species | Mouse |
Gene Type | protein-coding |
Description | branched chain aminotransferase 1, cytosolic |
Other Description | BCAT(c)|branched-chain-amino-acid aminotransferase, cytosolic |
Swissprots | Q7TMT2 P24288 |
Accessions | EDL10671 EDL10672 P24288 AK012821 AK013888 BAB29038 AK036309 BAC29379 AK138468 BAE23671 AK166971 BAE39154 AK167232 BAE39356 AK167368 BAE39464 AK168249 BAE40199 AW491045 BC053706 AAH53706 BY781109 U42443 AAB05673 X17502 CAA35543 XM_006536024 XP_006536087 XM_011241566 XP_011239868 NM_001024468 NP_001019639 NM_007532 NP_031558 |
Function | Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. |
Subcellular Location | Cytoplasm. |
Tissue Specificity | Expressed in brain and kidney. Overexpressed in MYC-induced brain tumors, lymphomas, as well as in a teratocarcinoma cell line. |
Top Pathways | Valine, leucine and isoleucine biosynthesis, Biosynthesis of amino acids, 2-Oxocarboxylic acid metabolism, Valine, leucine and isoleucine degradation, Pantothenate and CoA biosynthesis |
ECA39 CRISPR/Cas9 KO Plasmid (m) - sc-419297 from Santa Cruz Biotechnology
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ECA39 HDR Plasmid (m) - sc-419297-HDR from Santa Cruz Biotechnology
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ECA39 Double Nickase Plasmid (m) - sc-419297-NIC from Santa Cruz Biotechnology
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ECA39 Double Nickase Plasmid (m2) - sc-419297-NIC-2 from Santa Cruz Biotechnology
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ECA39 CRISPR Activation Plasmid (m) - sc-419297-ACT from Santa Cruz Biotechnology
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ECA39 CRISPR Activation Plasmid (m2) - sc-419297-ACT-2 from Santa Cruz Biotechnology
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ECA39 Lentiviral Activation Particles (m) - sc-419297-LAC from Santa Cruz Biotechnology
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ECA39 Lentiviral Activation Particles (m2) - sc-419297-LAC-2 from Santa Cruz Biotechnology
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ECA39 siRNA (m) - sc-77223 from Santa Cruz Biotechnology
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ECA39 shRNA Plasmid (m) - sc-77223-SH from Santa Cruz Biotechnology
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ECA39 shRNA (m) Lentiviral Particles - sc-77223-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU077871 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN27544 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND27544 from Sigma-Aldrich
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BCAT1 siRNA (Mouse) - CRM0350 from Cohesion Biosciences
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BCAT1 - MBS8203913 from MyBioSource
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shRNA set against Mouse BCAT1 (NM_007532.5) - SHH245754 from Creative biogene
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shRNA set against Mouse Bcat1(NM_007532.5) - SHG096315 from Creative biogene
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BCAT1 shRNA Plasmid (Mouse) - CHM0350 from Cohesion Biosciences
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BCAT1 miRNA 3'UTR clone - MiUTR1M-02145 from Creative biogene
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