Gene Symbol | CDIPT |
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Entrez Gene | 10423 |
Alt Symbol | PIS, PIS1 |
Species | Human |
Gene Type | protein-coding |
Description | CDP-diacylglycerol--inositol 3-phosphatidyltransferase |
Other Description | PI synthase|PtdIns synthase|phosphatidylinositol synthase |
Swissprots | Q6FGU1 B4DUV0 O14735 H3BTV1 Q6ZN70 |
Accessions | EAW79976 EAW79977 EAW79978 O14735 AF014807 AAB94860 AI696848 AK094468 BAG52872 AK097691 BAG53514 AK131227 BAG54756 AK131349 BAD18505 AK222676 BAD96396 AK290632 BAF83321 AK300805 BAG62462 AK310988 AK314544 AL050383 BC001444 AAH01444 BI490060 BT007301 AAP35965 BX333193 CR542016 CAG46813 XM_005255038 XP_005255095 NM_001286585 NP_001273514 NM_001286586 NP_001273515 NM_006319 NP_006310 NM_145752 |
Function | Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme. {ECO:0000269|PubMed:8110188}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Membrane {ECO:0000269|PubMed:8110188}. |
Tissue Specificity | Detected in placenta (at protein level). Widely expressed. Higher expression in adult liver and skeletal muscle, slightly lower levels seen in pancreas, kidney, lung, placenta, brain, heart, leukocyte, colon, small intestine, ovary, testis, prostate, thymus and spleen. In fetus, expressed in kidney, liver, lung and brain. {ECO:0000269|PubMed:8110188}. |
Top Pathways | Inositol phosphate metabolism, Glycerophospholipid metabolism, Phosphatidylinositol signaling system |
Human CDIPT1 full length protein - ab160982 from Abcam
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CDIPT Antibody Blocking Peptide - LS-E9913 from LifeSpan Bioscience
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Recombinant Human CDIPT Protein - H00010423-P01 from Novus Biologicals
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CDIPT-Antibody-Center-Blocking-Peptide - BP9044c from Abgent, a WuXi AppTec company
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CDIPT - H00010423-P01-02 from Acris Antibodies
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CDIPT fusion protein - ag18705 from Proteintech Group
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CDIPT fusion protein - ag18026 from Proteintech Group
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CDP-diacylglycerol--inositol 3-phosphatidyltransferase (CDIPT), Recombinant Protein - MBS1088923 from MyBioSource
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CDIPT Recombinant Protein Antigen - NBP2-49233PEP from Novus Biologicals
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CDIPT Peptide, Human - M34GP02856H from Creative Peptides
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Pis1 - AF1036 from Creative Peptides
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CDP-diacylglycerol--inositol 3-phosphatidyltransferase (CDIPT), Recombinant Protein - MBS7011211 from MyBioSource
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CDP-diacylglycerol--inositol 3-phosphatidyltransferase (pgsA), Recombinant Protein - MBS7026107 from MyBioSource
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CDP-diacylglycerol--inositol 3-phosphatidyltransferase (pgsA1), Recombinant Protein - MBS7026142 from MyBioSource
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