CDIPT
| Gene Symbol | CDIPT |
|---|---|
| Entrez Gene | 10423 |
| Alt Symbol | PIS, PIS1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | CDP-diacylglycerol--inositol 3-phosphatidyltransferase |
| Other Description | PI synthase|PtdIns synthase|phosphatidylinositol synthase |
| Swissprots | Q6FGU1 B4DUV0 O14735 H3BTV1 Q6ZN70 |
| Accessions | EAW79976 EAW79977 EAW79978 O14735 AF014807 AAB94860 AI696848 AK094468 BAG52872 AK097691 BAG53514 AK131227 BAG54756 AK131349 BAD18505 AK222676 BAD96396 AK290632 BAF83321 AK300805 BAG62462 AK310988 AK314544 AL050383 BC001444 AAH01444 BI490060 BT007301 AAP35965 BX333193 CR542016 CAG46813 XM_005255038 XP_005255095 NM_001286585 NP_001273514 NM_001286586 NP_001273515 NM_006319 NP_006310 NM_145752 |
| Function | Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme. {ECO:0000269|PubMed:8110188}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Membrane {ECO:0000269|PubMed:8110188}. |
| Tissue Specificity | Detected in placenta (at protein level). Widely expressed. Higher expression in adult liver and skeletal muscle, slightly lower levels seen in pancreas, kidney, lung, placenta, brain, heart, leukocyte, colon, small intestine, ovary, testis, prostate, thymus and spleen. In fetus, expressed in kidney, liver, lung and brain. {ECO:0000269|PubMed:8110188}. |
| Top Pathways | Inositol phosphate metabolism, Glycerophospholipid metabolism, Phosphatidylinositol signaling system |
PIS1 CRISPR/Cas9 KO Plasmid (h) - sc-409782 from Santa Cruz Biotechnology
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PIS1 HDR Plasmid (h) - sc-409782-HDR from Santa Cruz Biotechnology
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PIS1 Double Nickase Plasmid (h) - sc-409782-NIC from Santa Cruz Biotechnology
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PIS1 Double Nickase Plasmid (h2) - sc-409782-NIC-2 from Santa Cruz Biotechnology
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PIS1 CRISPR Activation Plasmid (h) - sc-409782-ACT from Santa Cruz Biotechnology
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PIS1 CRISPR Activation Plasmid (h2) - sc-409782-ACT-2 from Santa Cruz Biotechnology
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PIS1 Lentiviral Activation Particles (h) - sc-409782-LAC from Santa Cruz Biotechnology
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PIS1 Lentiviral Activation Particles (h2) - sc-409782-LAC-2 from Santa Cruz Biotechnology
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PIS1 siRNA (h) - sc-93119 from Santa Cruz Biotechnology
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PIS1 shRNA Plasmid (h) - sc-93119-SH from Santa Cruz Biotechnology
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PIS1 shRNA (h) Lentiviral Particles - sc-93119-V from Santa Cruz Biotechnology
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CDIPT RNAi - H00010423-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN5833 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5833 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06499 from Sigma-Aldrich
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CDIPT siRNA (Human) - CRH7068 from Cohesion Biosciences
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CDIPT RNAi - H00010423-R02 from Novus Biologicals
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CDIPT - MBS8201969 from MyBioSource
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shRNA set against Human CDIPT (NM_006319.3) - SHH260441 from Creative biogene
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shRNA set against Human CDIPT(NM_006319.3) - SHG163915 from Creative biogene
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Human CDIPT siRNA - orb267570 from Biorbyt
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CDIPT shRNA Plasmid (Human) - CHH7068 from Cohesion Biosciences
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CDIPT miRNA 3'UTR clone - MiUTR1H-01979 from Creative biogene
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