Gene Symbol | NDOR1 |
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Entrez Gene | 27158 |
Alt Symbol | NR1, bA350O14.9 |
Species | Human |
Gene Type | protein-coding |
Description | NADPH dependent diflavin oxidoreductase 1 |
Other Description | NADPH-dependent FMN and FAD-containing oxidoreductase|NADPH-dependent diflavin oxidoreductase 1 |
Swissprots | Q96BC6 D3YTH9 Q5VSG4 Q9UHB4 D3YTG6 Q86US9 |
Accessions | EAW88366 Q9UHB4 AF199509 AAF25205 AK026089 AK074403 AK225995 AK290026 BAF82715 AL133632 AY077845 AAL77754 BC015735 AAH15735 BC078668 BC093782 AAH93782 BC111943 AAI11944 BC143229 DA408370 DA858250 DQ892229 ABM83155 DQ895429 ABM86355 XM_011518545 XP_011516847 XM_011518546 XP_011516848 XM_011518547 XP_011516849 XM_011518548 XP_011516850 XR_929763 XR_929764 NM_001144026 NP_001137498 NM_001144027 NP_001137499 NM_001144028 NP_001137500 NM_014434 NP_055249 |
Function | Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins (By similarity). Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1. {ECO:0000255|HAMAP-Rule:MF_03178, ECO:0000269|PubMed:10625700, ECO:0000269|PubMed:20802492, ECO:0000269|PubMed:23596212}. |
Subcellular Location | Cytoplasm, perinuclear region {ECO:0000255|HAMAP-Rule:MF_03178, ECO:0000269|PubMed:10625700, ECO:0000269|PubMed:12871939}. Note=Concentrated in perinuclear structure. |
Tissue Specificity | Low expression in brain, heart, kidney, pancreas, prostate and skeletal muscle. Highest levels in the placenta. Expressed in cancer cell lines including promyelocytic leukemia, HeLaS3, chronic myelagenous leukemia, lymphoblastic leukemia, Burkitt's lymphoma, colorectal adenocarcinoma, lung carcinoma, and melanoma G-361. {ECO:0000269|PubMed:12871939}. |
NDOR1 CRISPR/Cas9 KO Plasmid (h) - sc-411974 from Santa Cruz Biotechnology
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NDOR1 HDR Plasmid (h) - sc-411974-HDR from Santa Cruz Biotechnology
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NDOR1 Double Nickase Plasmid (h) - sc-411974-NIC from Santa Cruz Biotechnology
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NDOR1 Double Nickase Plasmid (h2) - sc-411974-NIC-2 from Santa Cruz Biotechnology
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NDOR1 CRISPR Activation Plasmid (h) - sc-411974-ACT from Santa Cruz Biotechnology
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NDOR1 CRISPR Activation Plasmid (h2) - sc-411974-ACT-2 from Santa Cruz Biotechnology
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NDOR1 Lentiviral Activation Particles (h) - sc-411974-LAC from Santa Cruz Biotechnology
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NDOR1 Lentiviral Activation Particles (h2) - sc-411974-LAC-2 from Santa Cruz Biotechnology
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NDOR1 siRNA (h) - sc-92596 from Santa Cruz Biotechnology
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NDOR1 shRNA Plasmid (h) - sc-92596-SH from Santa Cruz Biotechnology
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NDOR1 shRNA (h) Lentiviral Particles - sc-92596-V from Santa Cruz Biotechnology
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NDOR1 RNAi - H00027158-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN15124 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15124 from Sigma-Aldrich
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NDOR1 siRNA (Human) - CRH9000 from Cohesion Biosciences
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shRNA set against Human NDOR1 (NM_014434.2) - SHH350340 from Creative biogene
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NDOR1 shRNA Plasmid (Human) - CHH9000 from Cohesion Biosciences
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NDOR1 miRNA 3'UTR clone - MiUTR4H-TG05904 from Creative biogene
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