| Gene Symbol |
Eif4e
|
| Entrez Gene |
13684
|
| Alt Symbol |
EG668879, Eif4e-ps, If4e, eIF-4E
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
eukaryotic translation initiation factor 4E
|
| Other Description |
eIF-4F 25 kDa subunit|mRNA cap-binding protein
|
| Swissprots |
P63073 P20415
|
| Accessions |
AAC62242 P63073 AK082867 BAC38660 AK133004 BAE21465 AK146757 AK167097 BAE39250 BC010759 AAH10759 BC085087 AAH85087 CN714483 M61731 AAA37545 XM_006500993 XP_006501056 NM_007917 NP_031943
|
| Function |
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. May play an important role in spermatogenesis through translational regulation of stage- specific mRNAs during germ cell development (By similarity). Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap. {ECO:0000250, ECO:0000269|PubMed:18805096}.
|
| Subcellular Location |
Cytoplasm, P-body {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:22900038}.
|
| Top Pathways |
Insulin signaling pathway, RNA transport, PI3K-Akt signaling pathway, mTOR signaling pathway
|