Eif4e

Gene Symbol	Eif4e
Entrez Gene	13684
Alt Symbol	EG668879, Eif4e-ps, If4e, eIF-4E
Species	Mouse
Gene Type	protein-coding
Description	eukaryotic translation initiation factor 4E
Other Description	eIF-4F 25 kDa subunit\|mRNA cap-binding protein
Swissprots	P63073 P20415
Accessions	AAC62242 P63073 AK082867 BAC38660 AK133004 BAE21465 AK146757 AK167097 BAE39250 BC010759 AAH10759 BC085087 AAH85087 CN714483 M61731 AAA37545 XM_006500993 XP_006501056 NM_007917 NP_031943
Function	Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. May play an important role in spermatogenesis through translational regulation of stage- specific mRNAs during germ cell development (By similarity). Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap. {ECO:0000250, ECO:0000269\|PubMed:18805096}.
Subcellular Location	Cytoplasm, P-body {ECO:0000250}. Cytoplasm {ECO:0000269\|PubMed:22900038}.
Top Pathways	Insulin signaling pathway, RNA transport, PI3K-Akt signaling pathway, mTOR signaling pathway

Category	Protein
Source	Yeast or E.coli or Baculovirus or Mammalian cell
Species	Mouse

Category	Protein
Prices	$970.00, $970.00, $1,190.00, $1,190.00, $1,455.00, $1,455.00, $1,915.00, $1,915.00
Sizes	500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source	E Coli or Yeast or Baculovirus or Mammalian Cell
Species	Mouse

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