Eif4e

Gene Symbol	Eif4e
Entrez Gene	13684
Alt Symbol	EG668879, Eif4e-ps, If4e, eIF-4E
Species	Mouse
Gene Type	protein-coding
Description	eukaryotic translation initiation factor 4E
Other Description	eIF-4F 25 kDa subunit|mRNA cap-binding protein
Swissprots	P63073 P20415
Accessions	AAC62242 P63073 AK082867 BAC38660 AK133004 BAE21465 AK146757 AK167097 BAE39250 BC010759 AAH10759 BC085087 AAH85087 CN714483 M61731 AAA37545 XM_006500993 XP_006501056 NM_007917 NP_031943
Function	Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. May play an important role in spermatogenesis through translational regulation of stage- specific mRNAs during germ cell development (By similarity). Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap. {ECO:0000250, ECO:0000269|PubMed:18805096}.
Subcellular Location	Cytoplasm, P-body {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:22900038}.
Top Pathways	Insulin signaling pathway, RNA transport, PI3K-Akt signaling pathway, mTOR signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

SignalSilence ® eIF4E siRNA II (Mouse Specific) - 6429 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

SignalSilence ® eIF4E siRNA I (Mouse Specific) - 6424 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Mouse

eIF4E CRISPR/Cas9 KO Plasmid (m) - sc-420148 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Mouse

eIF4E HDR Plasmid (m) - sc-420148-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

eIF4E Double Nickase Plasmid (m) - sc-420148-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

eIF4E Double Nickase Plasmid (m2) - sc-420148-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

eIF4E CRISPR Activation Plasmid (m) - sc-420148-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Mouse

eIF4E CRISPR Activation Plasmid (m2) - sc-420148-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Mouse

eIF4E Lentiviral Activation Particles (m) - sc-420148-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

eIF4E Lentiviral Activation Particles (m2) - sc-420148-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

eIF4E siRNA (m) - sc-35285 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

eIF4E shRNA Plasmid (m) - sc-35285-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

eIF4E shRNA (m) Lentiviral Particles - sc-35285-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

eIF4E siRNA (m2) - sc-35313 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

eIF4E shRNA Plasmid (m2) - sc-35313-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

eIF4E shRNA (m2) Lentiviral Particles - sc-35313-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

MISSION® esiRNA - EMU094691 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN30555 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND30555 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

EIF4E siRNA (Mouse) - CRM1172 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Mouse

EIF4E - MBS8202518 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Mouse

shRNA set against Mouse EIF4E (NM_007917.3) - SHH284641 from Creative biogene Category siRNA Species Reactivities Mouse

shRNA set against Mouse Eif4e(NM_007917.3) - SHH029675 from Creative biogene Category siRNA Species Reactivities Mouse

EIF4E shRNA Plasmid (Mouse) - CHM1172 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Mouse

EIF4E miRNA 3'UTR clone - MiUTR1M-04330 from Creative biogene Species Reactivities Mouse

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