NFKBIZ

Gene Symbol	NFKBIZ
Entrez Gene	64332
Alt Symbol	IKBZ, INAP, MAIL
Species	Human
Gene Type	protein-coding
Description	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
Other Description	I-kappa-B-zeta|IL-1 inducible nuclear ankyrin-repeat protein|Ikappa B-zeta variant 3|IkappaB-zeta|NF-kappa-B inhibitor zeta|ikB-zeta|ikappaBzeta|molecule possessing ankyrin repeats induced by lipopolysaccharide
Swissprots	Q8NAZ8 Q8IUL4 B3KNR2 Q9BYH8 D3DN54
Accessions	EAW79771 EAW79772 EAW79773 Q9BYH8 AB037925 BAB40337 AB074898 AF548362 AAN40698 AK054787 BAG51424 AK091782 BAC03746 AW004900 BC014587 BC060800 AAH60800 BM050734 BX492097 DA541852 DQ224339 ABB02425 NM_001005474 NP_001005474 NM_031419 NP_113607
Function	Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF- kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:16513645}. Note=Aggregated in dot-like structures. Colocalizes with NCOR2.
Tissue Specificity	Expressed at high levels in peripheral blood leukocytes and lung, at moderate levels in liver, placenta, and at low levels in spleen, kidney, skeletal muscle and heart. {ECO:0000269|PubMed:16513645}.
Top Pathways	Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

IκB-ζ Antibody - 9244 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Polyclonal

IκB-ζ (C-15) - sc-33421 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

IκB-ζ (H-50) - sc-66935 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

IκB-ζ (N-20) - sc-33419 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-IKB zeta antibody - ab124364 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-IKB zeta antibody [1E8] - ab118402 from Abcam Prices $370.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 1E8

Anti-NFKBIZ / IKBZ Antibody (aa250-300) - LS-C290668 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-NFKBIZ / IKBZ Antibody (aa678-728) - LS-C290669 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-NFKBIZ / IKBZ Antibody (C-Terminus) - LS-C135459 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-NFKBIZ / IKBZ Antibody (aa414-654, Biotin) - LS-C301076 from LifeSpan Bioscience Prices $435.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-NFKBIZ / IKBZ Antibody (aa422-651, FITC) - LS-C303574 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-NFKBIZ / IKBZ Antibody (aa422-651, Biotin) - LS-C301075 from LifeSpan Bioscience Prices $425.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-NFKBIZ / IKBZ Antibody (aa414-654, FITC) - LS-C303576 from LifeSpan Bioscience Prices $465.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-NFKBIZ / IKBZ Antibody (C-Terminus) - LS-C178927 from LifeSpan Bioscience Prices $255.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-NFKBIZ / IKBZ Antibody (aa186-199) - LS-C719 from LifeSpan Bioscience Prices $335.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-NFKBIZ / IKBZ Antibody (aa1-50) - LS-C290667 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-NFKBIZ / IKBZ Antibody (aa422-651) - LS-C294627 from LifeSpan Bioscience Prices $405.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-NFKBIZ / IKBZ Antibody (aa150-200) - LS-C290670 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-NFKBIZ / IKBZ Antibody (aa414-654) - LS-C294628 from LifeSpan Bioscience Prices $415.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-NFKBIZ / IKBZ Antibody (clone 1E8) - LS-C340592 from LifeSpan Bioscience Prices $350.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 1E8

Anti-NFKBIZ / IKBZ Antibody - LS-C70475 from LifeSpan Bioscience Prices $545.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

IKB zeta Antibody - NB100-56390 from Novus Biologicals Prices $99.00, $229.00 Sizes 25 µg, 100 µg Host Rabbit Clonality Polyclonal

IKB zeta Antibody (1E8) - NBP2-00642 from Novus Biologicals Prices $379.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 1E8

IKB zeta Antibody - NBP1-89835 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

IKB zeta Antibody - NBP2-16935 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

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