NFKBIZ

Gene Symbol	NFKBIZ
Entrez Gene	64332
Alt Symbol	IKBZ, INAP, MAIL
Species	Human
Gene Type	protein-coding
Description	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
Other Description	I-kappa-B-zeta|IL-1 inducible nuclear ankyrin-repeat protein|Ikappa B-zeta variant 3|IkappaB-zeta|NF-kappa-B inhibitor zeta|ikB-zeta|ikappaBzeta|molecule possessing ankyrin repeats induced by lipopolysaccharide
Swissprots	Q8NAZ8 Q8IUL4 B3KNR2 Q9BYH8 D3DN54
Accessions	EAW79771 EAW79772 EAW79773 Q9BYH8 AB037925 BAB40337 AB074898 AF548362 AAN40698 AK054787 BAG51424 AK091782 BAC03746 AW004900 BC014587 BC060800 AAH60800 BM050734 BX492097 DA541852 DQ224339 ABB02425 NM_001005474 NP_001005474 NM_031419 NP_113607
Function	Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF- kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:16513645}. Note=Aggregated in dot-like structures. Colocalizes with NCOR2.
Tissue Specificity	Expressed at high levels in peripheral blood leukocytes and lung, at moderate levels in liver, placenta, and at low levels in spleen, kidney, skeletal muscle and heart. {ECO:0000269|PubMed:16513645}.
Top Pathways	Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

NFKBIZ / IKBZ Antibody Blocking Peptide - LS-E21060 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human IKB zeta Protein - H00064332-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Nfkbiz Blocking Peptide - 33R-9778 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Human IkBz Protein - abx067217 from Abbexa Category Protein Source E.coli Species Human

NFKBIZ / IKBZ - H00064332-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

NFKBIZ / IKBZ - H00064332-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

NFKBIZ fusion protein - ag6014 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

NFKBIZ fusion protein - ag5120 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Inhibitory Subunit Of NF Kappa B Zeta (IkBz) - RPC249Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Inhibitory Subunit Of NF Kappa B Zeta (IkBz) - RPC249Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Inhibitory Subunit Of NF Kappa B Zeta (IkBz) - RPC249Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human NF-kappa-B inhibitor zeta(NFKBIZ) - CSB-YP880137HU CSB-EP880137HU CSB-BP880137HU CSB-MP880137HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

IKB zeta Recombinant Protein Antigen - NBP1-89835PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

NFKBIZ Peptide, Human - M34GP10348H from Creative Peptides Category Peptide Source Synthetic. Species Human

NFKBIZ Recombinant Protein (OPCD04225) - OPCD04225 from Aviva Systems Biology Category Protein Source E.coli Species Human

IKB zeta Recombinant Protein Antigen - NBP2-57948PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Inhibitory Subunit Of NF Kappa B Zeta (IkBz), Recombinant Protein - MBS2018436 from MyBioSource Category Protein Prices $190.00, $395.00, $610.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Human

NF-kappa-B inhibitor zeta (NFKBIZ), Recombinant Protein - MBS1351762 from MyBioSource Category Protein Prices $1,525.00, $1,525.00, $1,755.00, $1,755.00, $2,620.00, $2,620.00, $3,060.00, $3,060.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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