| Gene Symbol |
NFKBIZ
|
| Entrez Gene |
64332
|
| Alt Symbol |
IKBZ, INAP, MAIL
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
|
| Other Description |
I-kappa-B-zeta|IL-1 inducible nuclear ankyrin-repeat protein|Ikappa B-zeta variant 3|IkappaB-zeta|NF-kappa-B inhibitor zeta|ikB-zeta|ikappaBzeta|molecule possessing ankyrin repeats induced by lipopolysaccharide
|
| Swissprots |
Q8NAZ8 Q8IUL4 B3KNR2 Q9BYH8 D3DN54
|
| Accessions |
EAW79771 EAW79772 EAW79773 Q9BYH8 AB037925 BAB40337 AB074898 AF548362 AAN40698 AK054787 BAG51424 AK091782 BAC03746 AW004900 BC014587 BC060800 AAH60800 BM050734 BX492097 DA541852 DQ224339 ABB02425 NM_001005474 NP_001005474 NM_031419 NP_113607
|
| Function |
Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF- kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:16513645}. Note=Aggregated in dot-like structures. Colocalizes with NCOR2.
|
| Tissue Specificity |
Expressed at high levels in peripheral blood leukocytes and lung, at moderate levels in liver, placenta, and at low levels in spleen, kidney, skeletal muscle and heart. {ECO:0000269|PubMed:16513645}.
|
| Top Pathways |
Transcriptional misregulation in cancer
|