| Gene Symbol |
PLCD3
|
| Entrez Gene |
113026
|
| Alt Symbol |
PLC-delta-3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phospholipase C, delta 3
|
| Other Description |
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3|1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-3|PLC delta3|phosphoinositide phospholipase C-delta-3
|
| Swissprots |
Q96FL6 Q8TEC1 Q8N3E9 Q8TF37
|
| Accessions |
CBF62945 CBF74688 CBU87821 CBU96768 EAW51544 EAW51545 EAW51546 EAW51547 Q8N3E9 AB075844 BAB85550 AK074240 BAB85029 AL834392 CAD39054 BC010668 AAH10668 BC072384 AAH72384 BU621728 DA128483 HY169731 XM_011524253 XP_011522555 NM_133373 NP_588614
|
| Function |
Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow.
|
| Subcellular Location |
Membrane; Peripheral membrane protein. Cytoplasm. Cleavage furrow. Note=Localizes at the cleavage furrow during cytokinesis.
|
| Tissue Specificity |
Present in corneal epithelial cells (at protein level). {ECO:0000269|PubMed:15505048}.
|
| Top Pathways |
Calcium signaling pathway, Inositol phosphate metabolism, Phosphatidylinositol signaling system
|