PLCD3

Gene Symbol PLCD3
Entrez Gene 113026
Alt Symbol PLC-delta-3
Species Human
Gene Type protein-coding
Description phospholipase C, delta 3
Other Description 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3|1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-3|PLC delta3|phosphoinositide phospholipase C-delta-3
Swissprots Q96FL6 Q8TEC1 Q8N3E9 Q8TF37
Accessions CBF62945 CBF74688 CBU87821 CBU96768 EAW51544 EAW51545 EAW51546 EAW51547 Q8N3E9 AB075844 BAB85550 AK074240 BAB85029 AL834392 CAD39054 BC010668 AAH10668 BC072384 AAH72384 BU621728 DA128483 HY169731 XM_011524253 XP_011522555 NM_133373 NP_588614
Function Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow.
Subcellular Location Membrane; Peripheral membrane protein. Cytoplasm. Cleavage furrow. Note=Localizes at the cleavage furrow during cytokinesis.
Tissue Specificity Present in corneal epithelial cells (at protein level). {ECO:0000269|PubMed:15505048}.
Top Pathways Calcium signaling pathway, Inositol phosphate metabolism, Phosphatidylinositol signaling system

PLC δ3 (L-15) - sc-30826 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PLC δ3 (L-15): sc-30826. Immunofluorescence staining of methanol-fixed NIH/3T3 cells showing membrane localization.

PLC δ3 (H-14) - sc-30825 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-PLC-delta-3 antibody - ab151594 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-PLC-delta-3 antibody (ab151594) at 1/1000 dilution + HCT116 whole cell lysate at 30 µg

Anti-PLC-delta-3 antibody - ab121859 from Abcam

Prices $443.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab121859, at 1/200 dilution, staining PLC-delta-3 in hepatocytes of paraffin-embedded Human liver tissue by Immunohistochemistry.

Anti-PLC-delta-3 antibody - ab123668 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-PLC-delta-3 antibody (ab123668) at 1/100 dilution + Mouse liver tissue lysates at 35 µg

Anti-PLCD3 Antibody (aa148-344) - LS-C131412 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-PLCD3 Antibody (aa60-89, APC) - LS-C239145 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLCD3 Antibody (aa60-89, AP) - LS-C239146 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLCD3 Antibody (aa60-89, Biotin) - LS-C239147 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLCD3 Antibody (aa60-89, PE) - LS-C239149 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLCD3 Antibody (aa60-89, Azide-free, HRP) - LS-C248494 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLCD3 Antibody (aa60-89, FITC) - LS-C239148 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLCD3 Antibody (aa59-89) - LS-C324092 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PLCD3 Antibody (aa60-89) - LS-C163776 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
PLCD3 Antibody western blot of mouse liver tissue lysates (35 ug/lane). The PLCD3 antibody detected the PLCD3 protein (arrow).

PLC-delta 3 Antibody - AF5315 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal
Western blot shows lysates of HT‑29 human colon adenocarcinoma cell line, 293T human embryonic kidney cell line, Jurkat human acute T cell leukemia cell line, and NIH‑3T3 mouse embryonic fibroblast cell line. PVDF Membrane was probed with 1 µg/mL of Goat Anti-Human/Mouse PLC‑δ3 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5315) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109). Specific bands were detected for PLC‑δ3 at approximately 100‑110 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

PLC-delta 3 Antibody - NBP1-85969 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: PLC-delta 3 Antibody [NBP1-85969] - Staining of human colon shows strong cytoplasmic positivity in glandular cells.

PLC-delta 3 Antibody - NBP2-19862 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PLC-delta 3 Antibody [NBP2-19862] - Sample (30 ug of whole cell lysate) A: HCT116 7. 5% SDS PAGE gel, diluted at 1:1000.

Anti-PLCD3 antibody produced in rabbit - HPA025711 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-PLCD3: <B>Cat. No. HPA025711</B>: Immunohistochemical staining of human liver shows strong cytoplasmic positivity in hepatocytes.

ANTI-PLCD3 (N-TERM) antibody produced in rabbit - SAB1304273 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-PLCD3 (N-term): <B>Cat. No. SAB1304273</B>: PLCD3 Antibody (N-term) western blot analysis in mouse liver tissue lysates (35 μg/lane).

PLCD3-Antibody-N-term - AP14654a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
PLCD3 Antibody (N-term) (Cat. #AP14654a) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the PLCD3 antibody detected the PLCD3 protein (arrow).

PLCD3 Antibody - N-terminal region (OAAB10980) - OAAB10980 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

Human/Mouse PLC-δ3 Antibody - AF5315 from R&D Systems

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Detection of Human and Mouse PLC-d3 by Western Blot. Western blot shows lysates of HT-29 human colon adenocarcinoma cell line, 293T human embryonic kidney cell line, Jurkat human acute T cell leukemia cell line, and NIH-3T3 mouse embryonic fibroblast cell line. PVDF Membrane was probed with 1 µg/mL of Goat Anti-Human/Mouse PLC-d3 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5315) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109 ). Specific bands were detected for PLC-d3 at approximately 100-110 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1 .
Detection of Human and Mouse PLC‑delta 3 by Western Blot. Western blot shows lysates of HT‑29 human colon adenocarcinoma cell line, 293T human embryonic kidney cell line, Jurkat human acute T cell leukemia cell line, and NIH‑3T3 mouse embryonic fibroblast cell line. PVDF Membrane was probed with 1 µg/mL of Goat Anti-Human/Mouse PLC‑delta 3 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5315) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109). Specific bands were detected for PLC‑delta 3 at approximately 100‑110 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

PLCD3 antibody - 16792-1-AP from Acris Antibodies

Prices $270.00
Sizes 150 µl
Host Rabbit
Clonality Polyclonal
A549 cells were subjected to SDS PAGE followed by western blot with 16792-1-AP( PLCD3 Antibody) at dilution of 1:600

PLCD3 (N-term) antibody - AP53337PU-N from Acris Antibodies

Prices $330.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of PLCD3 Antibody (N-term) Cat.-No AP53337PU-N in mouse liver tissue lysates (35ug/lane). This demonstrates the PLCD3 antibody detected the PLCD3 protein (arrow).
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