PLCD3

Gene Symbol	PLCD3
Entrez Gene	113026
Alt Symbol	PLC-delta-3
Species	Human
Gene Type	protein-coding
Description	phospholipase C, delta 3
Other Description	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3|1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-3|PLC delta3|phosphoinositide phospholipase C-delta-3
Swissprots	Q96FL6 Q8TEC1 Q8N3E9 Q8TF37
Accessions	CBF62945 CBF74688 CBU87821 CBU96768 EAW51544 EAW51545 EAW51546 EAW51547 Q8N3E9 AB075844 BAB85550 AK074240 BAB85029 AL834392 CAD39054 BC010668 AAH10668 BC072384 AAH72384 BU621728 DA128483 HY169731 XM_011524253 XP_011522555 NM_133373 NP_588614
Function	Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Essential for trophoblast and placental development. May participate in cytokinesis by hydrolyzing PIP2 at the cleavage furrow.
Subcellular Location	Membrane; Peripheral membrane protein. Cytoplasm. Cleavage furrow. Note=Localizes at the cleavage furrow during cytokinesis.
Tissue Specificity	Present in corneal epithelial cells (at protein level). {ECO:0000269|PubMed:15505048}.
Top Pathways	Calcium signaling pathway, Inositol phosphate metabolism, Phosphatidylinositol signaling system

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PLC-delta-3 protein fragment - ab164992 from Abcam Category Protein Source Wheat germ Species Human

PLCD3 Antibody Blocking Peptide - LS-E3469 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PLC-delta 3 Partial Recombinant Protein - H00113026-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

PLCD3-Antibody-N-term-Blocking-Peptide - BP14654a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PLCD3 - H00113026-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PLCD3 - H00113026-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PLCD3 fusion protein - Ag10249 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human PLCD3, His-tagged - PLCD3-1765H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3(PLCD3) - CSB-YP822696HU CSB-EP822696HU CSB-BP822696HU CSB-MP822696HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 (PLCD3), Recombinant Protein - MBS1423933 from MyBioSource Category Protein Prices $1,610.00, $1,610.00, $1,835.00, $1,835.00, $2,765.00, $2,765.00, $3,225.00, $3,225.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

PLC-delta 3 Recombinant Protein Antigen - NBP1-85969PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

PLCD3 Peptide, Human - M34GP11899H from Creative Peptides Category Peptide Source Synthetic. Species Human

PLCD3 Recombinant Protein (OPCD00190) - OPCD00190 from Aviva Systems Biology Category Protein Source E.coli Species Human

Phospholipase C Delta 3, Recombinant Protein - MBS2034315 from MyBioSource Category Protein Prices $205.00, $460.00, $715.00 Sizes 10 µg, 50 µg, 100 µg Source E Coli Species Human

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