Gene Symbol | Lep |
---|---|
Entrez Gene | 16846 |
Alt Symbol | ob, obese |
Species | Mouse |
Gene Type | protein-coding |
Description | leptin |
Other Description | obesity factor |
Swissprots | P41160 |
Accessions | AAA64213 EDL13794 EDL13795 P41160 AK030984 BAC27202 AK142589 BAE25117 BC038162 BC125245 AAI25246 FJ374142 ACJ09173 HQ166716 ADM72802 U18812 AAA64564 XM_006504999 XP_006505062 NM_008493 NP_032519 |
Function | May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass. |
Subcellular Location | Secreted {ECO:0000305}. |
Top Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Adipocytokine signaling pathway, Non-alcoholic fatty liver disease (NAFLD), AMPK signaling pathway |