Gene Symbol | Lep |
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Entrez Gene | 16846 |
Alt Symbol | ob, obese |
Species | Mouse |
Gene Type | protein-coding |
Description | leptin |
Other Description | obesity factor |
Swissprots | P41160 |
Accessions | AAA64213 EDL13794 EDL13795 P41160 AK030984 BAC27202 AK142589 BAE25117 BC038162 BC125245 AAI25246 FJ374142 ACJ09173 HQ166716 ADM72802 U18812 AAA64564 XM_006504999 XP_006505062 NM_008493 NP_032519 |
Function | May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass. |
Subcellular Location | Secreted {ECO:0000305}. |
Top Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Adipocytokine signaling pathway, Non-alcoholic fatty liver disease (NAFLD), AMPK signaling pathway |
Ob CRISPR/Cas9 KO Plasmid (m) - sc-421412 from Santa Cruz Biotechnology
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Ob HDR Plasmid (m) - sc-421412-HDR from Santa Cruz Biotechnology
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Ob Double Nickase Plasmid (m) - sc-421412-NIC from Santa Cruz Biotechnology
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Ob Double Nickase Plasmid (m2) - sc-421412-NIC-2 from Santa Cruz Biotechnology
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Ob CRISPR Activation Plasmid (m) - sc-421412-ACT from Santa Cruz Biotechnology
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Ob CRISPR Activation Plasmid (m2) - sc-421412-ACT-2 from Santa Cruz Biotechnology
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Ob Lentiviral Activation Particles (m) - sc-421412-LAC from Santa Cruz Biotechnology
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Ob Lentiviral Activation Particles (m2) - sc-421412-LAC-2 from Santa Cruz Biotechnology
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Ob siRNA (m) - sc-37190 from Santa Cruz Biotechnology
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Ob shRNA Plasmid (m) - sc-37190-SH from Santa Cruz Biotechnology
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Ob shRNA (m) Lentiviral Particles - sc-37190-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN34719 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND34719 from Sigma-Aldrich
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LEP siRNA (Mouse) - CRM2330 from Cohesion Biosciences
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shRNA set against Mouse LEP (NM_008493.3) - SHH329611 from Creative biogene
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shRNA set against Mouse Lep(NM_008493.3) - SHH146333 from Creative biogene
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Mouse LEP siRNA - orb281806 from Biorbyt
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LEP shRNA Plasmid (Mouse) - CHM2330 from Cohesion Biosciences
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LEP miRNA 3'UTR clone - MiUTR1M-06599 from Creative biogene
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