CLEC7A

Gene Symbol CLEC7A
Entrez Gene 64581
Alt Symbol BGR, CANDF4, CLECSF12, DECTIN1
Species Human
Gene Type protein-coding
Description C-type lectin domain family 7, member A
Other Description C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12|C-type lectin domain family 7 member A|C-type lectin superfamily member 12|DC-associated C-type lectin 1|beta-glucan receptor|dectin-1|dendritic cell-associated C-type lectin 1|dendritic cell-associated C-type lectin-1|lectin-like receptor 1
Swissprots Q96PA7 Q96D32 Q96PA8 Q96PA6 Q96LD3 Q9BXN2 B7Z5A9 B7Z5B9 B7Z494 Q96DR9 Q96PA5 Q96PA4 Q9H1K3 B2R861 Q6IPS7
Accessions CAF63003 CAF63006 EAW96144 EAW96145 EAW96146 EAW96147 EAW96148 EAW96149 EAW96150 EAW96151 EAW96152 EAW96153 EAW96154 EAW96155 Q9BXN2 AA361063 AF313468 AAK37473 AF313469 AAK37474 AF400595 AAL11711 AF400596 AAL11712 AF400597 AAL11713 AF400598 AAL11714 AF400599 AAL11715 AF400600 AAL11716 AF400601 AAL11717 AF400602 AAL11718 AJ312372 CAC43846 AJ312373 CAC43847 AK294111 BAH11674 AK295108 BAH11976 AK297028 BAH12480 AK298679 BAH12845 AK298724 BAH12855 AK313247 BAG36058 AY009090 AAG33923 AY026769 AAK20114 AY026770 AAK20115 AY026771 AAK20116 AY358685 AAQ89048 AY359002 AAQ89361 BC013385 AAH13385 BC071746 AAH71746 BC093829 AAH93829 BC093831 AAH93831 CR749536 CAH18342 DA193873 HQ447540 ADQ32026 XM_005253467 XP_005253524 XM_006719135 XP_006719198 NM_022570 NP_072092 NM_197947 NP_922938 NM_197948 NP_922939 NM_197949 NP_922940 NM_197950 NP_922941 NM_197954 NP_922945 NR_125336 NM_197951 NM_197952 NM_197953
Function Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation (By similarity). {ECO:0000250}.
Subcellular Location Isoform 6: Cytoplasm {ECO:0000305}.
Tissue Specificity Highly expressed in peripheral blood leukocytes and dendritic cells. Detected in spleen, bone marrow, lung, muscle, stomach and placenta. {ECO:0000269|PubMed:11470510, ECO:0000269|PubMed:11491532, ECO:0000269|PubMed:11567029, ECO:0000269|PubMed:11745369, ECO:0000269|PubMed:12423684}.
Top Pathways Phagosome, Tuberculosis

Dectin-1 Antibody - 9051 from Cell Signaling Technology

Prices $239.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from 293T cells, mock transfected (-) or transfected with a construct expressing Myc/DDK-tagged full-length human Dectin-1 (hDectin-1-Myc/DDK; +), using Dectin-1 Antibody.

Dectin-1 (N-16) - sc-26094 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Dectin-1 (N-16): sc-26094. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

Anti-beta Glucan Receptor antibody - ab140039 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescence of beta Glucan receptor in Human spleen tissue with ab140039 at 20 ug/mL.

Anti-beta Glucan Receptor antibody - ab189968 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed paraffin-embedded Human Testis tissue labeling beta Glucan Receptor with ab189968 at 2.5 µg/ml.

Anti-beta Glucan Receptor antibody - ab189629 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-beta Glucan Receptor antibody (ab189629) at 1/500 dilutionLane 1 : Mouse thymusLane 2 : HeLa cell extractLane 3 : Jurkat cell extract

Anti-beta Glucan Receptor antibody - ab172651 from Abcam

Prices $376.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-beta Glucan Receptor antibody (ab172651) at 1/500 dilutionLane 1 : beta Glucan Receptor transfected 293T cell line lysateLane 2 : Non-transfected 293T cell line lysateLysates/proteins at 15 µl per lane.SecondaryLane 1 : Goat Anti-Rabbit IgG (H&L)-HRP Conjugate at 1/2500 dilutionLane 2 : Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilutiondeveloped using the ECL technique

Anti-beta Glucan Receptor antibody - ab189961 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded human colon vessels labeling beta Glucan Receptor with ab189961 at 10 µg/ml.

Anti-beta Glucan Receptor antibody [BD6] - ab82883 from Abcam

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone BD6
Staining of human peripheral blood monocytes with ab82883.

Anti-beta Glucan Receptor antibody [GE2] - Low endotoxin, Azide free - ab82888 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone GE2
Flow cytometry analysis of A549 cells, staining beta Glucan Receptor (green) with ab82888. Cells were infected with swollen conidia of A. fumigatus 13073 at an MOI of 10 or incubated with PBS (Control) for 30 min. Subsequently, the cells were stained with isotype (IC) antibody or the primary antibody and analyzed by flow cytometry. A PE-conjugated goat anti-mouse IgG was used as the secondary antibody.

Anti-CLEC7A / Dectin 1 Antibody (APC) - LS-C64627 from LifeSpan Bioscience

Prices $590.00
Sizes 100 tst
Host Mouse
Clonality Monoclonal

Anti-CLEC7A / Dectin 1 Antibody (APC) - LS-C64629 from LifeSpan Bioscience

Prices $590.00
Sizes 100 tst
Host Rat
Clonality Monoclonal

Anti-CLEC7A / Dectin 1 Antibody - LS-C123381 from LifeSpan Bioscience

Prices $710.00
Sizes 500 µg
Host Rat
Clonality Monoclonal

Anti-CLEC7A / Dectin 1 Antibody - LS-C123380 from LifeSpan Bioscience

Prices $530.00
Sizes 250 µg
Host Rat
Clonality Monoclonal

Anti-CLEC7A / Dectin 1 Antibody (clone BD6, FITC) - LS-C125445 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone BD6

Anti-CLEC7A / Dectin 1 Antibody (FITC) - LS-C125443 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-CLEC7A / Dectin 1 Antibody - LS-C125444 from LifeSpan Bioscience

Prices $475.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal

Anti-CLEC7A / Dectin 1 Antibody (CF) - LS-C128549 from LifeSpan Bioscience

Prices $445.00
Sizes 100 tst
Host Mouse
Clonality Monoclonal

Anti-CLEC7A / Dectin 1 Antibody - LS-C123382 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rat
Clonality Monoclonal

Anti-CLEC7A / Dectin 1 Antibody (FITC) - LS-C128551 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rat
Clonality Monoclonal

Anti-CLEC7A / Dectin 1 Antibody (PE) - LS-C128552 from LifeSpan Bioscience

Prices $495.00
Sizes 100 tst
Host Rat
Clonality Monoclonal

Anti-CLEC7A / Dectin 1 Antibody (Biotin) - LS-C128550 from LifeSpan Bioscience

Prices $560.00
Sizes 100 µg
Host Rat
Clonality Monoclonal

Anti-CLEC7A / Dectin 1 Antibody - LS-C128554 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-CLEC7A / Dectin 1 Antibody - LS-C147016 from LifeSpan Bioscience

Prices $410.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CLEC7A / Dectin 1 Antibody (PerCP) - LS-C128555 from LifeSpan Bioscience

Prices $575.00
Sizes 100 tst
Host Mouse
Clonality Monoclonal

Anti-CLEC7A / Dectin 1 Antibody (clone 2A11, FITC) - LS-C188262 from LifeSpan Bioscience

Prices $360.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 2A11
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