CLEC7A

Gene Symbol	CLEC7A
Entrez Gene	64581
Alt Symbol	BGR, CANDF4, CLECSF12, DECTIN1
Species	Human
Gene Type	protein-coding
Description	C-type lectin domain family 7, member A
Other Description	C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12|C-type lectin domain family 7 member A|C-type lectin superfamily member 12|DC-associated C-type lectin 1|beta-glucan receptor|dectin-1|dendritic cell-associated C-type lectin 1|dendritic cell-associated C-type lectin-1|lectin-like receptor 1
Swissprots	Q96PA7 Q96D32 Q96PA8 Q96PA6 Q96LD3 Q9BXN2 B7Z5A9 B7Z5B9 B7Z494 Q96DR9 Q96PA5 Q96PA4 Q9H1K3 B2R861 Q6IPS7
Accessions	CAF63003 CAF63006 EAW96144 EAW96145 EAW96146 EAW96147 EAW96148 EAW96149 EAW96150 EAW96151 EAW96152 EAW96153 EAW96154 EAW96155 Q9BXN2 AA361063 AF313468 AAK37473 AF313469 AAK37474 AF400595 AAL11711 AF400596 AAL11712 AF400597 AAL11713 AF400598 AAL11714 AF400599 AAL11715 AF400600 AAL11716 AF400601 AAL11717 AF400602 AAL11718 AJ312372 CAC43846 AJ312373 CAC43847 AK294111 BAH11674 AK295108 BAH11976 AK297028 BAH12480 AK298679 BAH12845 AK298724 BAH12855 AK313247 BAG36058 AY009090 AAG33923 AY026769 AAK20114 AY026770 AAK20115 AY026771 AAK20116 AY358685 AAQ89048 AY359002 AAQ89361 BC013385 AAH13385 BC071746 AAH71746 BC093829 AAH93829 BC093831 AAH93831 CR749536 CAH18342 DA193873 HQ447540 ADQ32026 XM_005253467 XP_005253524 XM_006719135 XP_006719198 NM_022570 NP_072092 NM_197947 NP_922938 NM_197948 NP_922939 NM_197949 NP_922940 NM_197950 NP_922941 NM_197954 NP_922945 NR_125336 NM_197951 NM_197952 NM_197953
Function	Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation (By similarity). {ECO:0000250}.
Subcellular Location	Isoform 6: Cytoplasm {ECO:0000305}.
Tissue Specificity	Highly expressed in peripheral blood leukocytes and dendritic cells. Detected in spleen, bone marrow, lung, muscle, stomach and placenta. {ECO:0000269|PubMed:11470510, ECO:0000269|PubMed:11491532, ECO:0000269|PubMed:11567029, ECO:0000269|PubMed:11745369, ECO:0000269|PubMed:12423684}.
Top Pathways	Phagosome, Tuberculosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human beta Glucan Receptor full length protein - ab163849 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

CLEC7A / Dectin 1 Antibody Blocking Peptide - LS-E2390 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CLEC7A / Dectin 1 Antibody Blocking Peptide - LS-E31269 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Dectin-1/CLEC7A Recombinant Protein - H00064581-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

CLEC7A-Antibody-N-term-Blocking-peptide - BP13369a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Dectin-1/CLEC7A, CF - 1859-DC-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Thr66-Met201, with an N-terminal 10-His tag

Human CLEC7A protein - orb138578 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Cells Species Human

Human CLECSF12 (Fc Tag) protein - orb179530 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Cells Species Human

Human Dectin-1 (Fc Tag) protein - orb232218 from Biorbyt Category Protein Prices $400.00, $816.00 Sizes 50 μg, 200 μg Species Human

Dectin 1 Blocking Peptide - 33R-10980 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

CLEC7A / Dectin-1 - H00064581-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CLEC7A / Dectin-1 - H00064581-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CLEC7A / Dectin-1 (Center) Control Peptide - AP55427CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

CLEC7A Peptide - 6833P from ProSci Category Peptide Species Human

CLEC7A fusion protein - Ag19019 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

CLEC7A fusion protein - Ag18924 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human CLEC7A, His-tagged - CLEC7A-11322H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human CLEC7A - CLEC7A-260H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Human CLEC7A, Fc-tagged - CLEC7A-261H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Human CLEC7A, His-tagged - CLEC7A-746H from Creative Biomart Category Protein Source NSO Cells Species Human

Human CLEC7A / Dectin-1 / CLECSF12 Protein - 10215-HNCH-50 from Sino Biological Category Protein Source Human Cells Species Human

Human CLEC7A / Dectin-1 / CLECSF12 Protein (Fc Tag) - 10215-H01H-50 from Sino Biological Category Protein Source Human Cells Species Human

Dectin-1 - pro10240 from Covalab Category Protein Source HEK 293 cells Species Mouse

Recombinant Human C-type lectin domain family 7 member A(CLEC7A) - CSB-YP883623HU CSB-EP883623HU CSB-BP883623HU CSB-MP883623HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Dectin-1 Blocking Peptide - 3891BP-50 from Biovision Category Peptide Prices $95.00 Sizes 50 µg

Search more