CLEC7A

Gene Symbol CLEC7A
Entrez Gene 64581
Alt Symbol BGR, CANDF4, CLECSF12, DECTIN1
Species Human
Gene Type protein-coding
Description C-type lectin domain family 7, member A
Other Description C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12|C-type lectin domain family 7 member A|C-type lectin superfamily member 12|DC-associated C-type lectin 1|beta-glucan receptor|dectin-1|dendritic cell-associated C-type lectin 1|dendritic cell-associated C-type lectin-1|lectin-like receptor 1
Swissprots Q96PA7 Q96D32 Q96PA8 Q96PA6 Q96LD3 Q9BXN2 B7Z5A9 B7Z5B9 B7Z494 Q96DR9 Q96PA5 Q96PA4 Q9H1K3 B2R861 Q6IPS7
Accessions CAF63003 CAF63006 EAW96144 EAW96145 EAW96146 EAW96147 EAW96148 EAW96149 EAW96150 EAW96151 EAW96152 EAW96153 EAW96154 EAW96155 Q9BXN2 AA361063 AF313468 AAK37473 AF313469 AAK37474 AF400595 AAL11711 AF400596 AAL11712 AF400597 AAL11713 AF400598 AAL11714 AF400599 AAL11715 AF400600 AAL11716 AF400601 AAL11717 AF400602 AAL11718 AJ312372 CAC43846 AJ312373 CAC43847 AK294111 BAH11674 AK295108 BAH11976 AK297028 BAH12480 AK298679 BAH12845 AK298724 BAH12855 AK313247 BAG36058 AY009090 AAG33923 AY026769 AAK20114 AY026770 AAK20115 AY026771 AAK20116 AY358685 AAQ89048 AY359002 AAQ89361 BC013385 AAH13385 BC071746 AAH71746 BC093829 AAH93829 BC093831 AAH93831 CR749536 CAH18342 DA193873 HQ447540 ADQ32026 XM_005253467 XP_005253524 XM_006719135 XP_006719198 NM_022570 NP_072092 NM_197947 NP_922938 NM_197948 NP_922939 NM_197949 NP_922940 NM_197950 NP_922941 NM_197954 NP_922945 NR_125336 NM_197951 NM_197952 NM_197953
Function Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation (By similarity). {ECO:0000250}.
Subcellular Location Isoform 6: Cytoplasm {ECO:0000305}.
Tissue Specificity Highly expressed in peripheral blood leukocytes and dendritic cells. Detected in spleen, bone marrow, lung, muscle, stomach and placenta. {ECO:0000269|PubMed:11470510, ECO:0000269|PubMed:11491532, ECO:0000269|PubMed:11567029, ECO:0000269|PubMed:11745369, ECO:0000269|PubMed:12423684}.
Top Pathways Phagosome, Tuberculosis

Dectin-1 CRISPR/Cas9 KO Plasmid (h) - sc-417053 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dectin-1 HDR Plasmid (h) - sc-417053-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dectin-1 Double Nickase Plasmid (h) - sc-417053-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dectin-1 Double Nickase Plasmid (h2) - sc-417053-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dectin-1 CRISPR Activation Plasmid (h) - sc-417053-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dectin-1 CRISPR Activation Plasmid (h2) - sc-417053-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dectin-1 Lentiviral Activation Particles (h) - sc-417053-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dectin-1 Lentiviral Activation Particles (h2) - sc-417053-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Dectin-1 siRNA (h) - sc-63276 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Dectin-1 shRNA Plasmid (h) - sc-63276-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Dectin-1 shRNA (h) Lentiviral Particles - sc-63276-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Dectin-1/CLEC7A RNAi - H00064581-R10 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Dectin-1/CLEC7A RNAi - H00064581-R13 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Dectin-1/CLEC7A RNAi - H00064581-R15 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Dectin-1/CLEC7A RNAi - H00064581-R18 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Dectin-1/CLEC7A RNAi - H00064581-R17 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Dectin-1/CLEC7A RNAi - H00064581-R16 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Dectin-1/CLEC7A RNAi - H00064581-R14 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU100561 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN6224 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6224 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

CLEC7A siRNA (Human) - CRJ2036 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Dectin-1/CLEC7A RNAi - H00064581-R11 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

Dectin-1/CLEC7A RNAi - H00064581-R12 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CLEC7A - MBS8221238 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human
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