CIRBP

Gene Symbol CIRBP
Entrez Gene 1153
Alt Symbol CIRP
Species Human
Gene Type protein-coding
Description cold inducible RNA binding protein
Other Description A18 hnRNP|cold inducible RNA-binding protein|cold-inducible RNA-binding protein|glycine-rich RNA binding protein
Swissprots B3KT17 Q14011 B4E2X2
Accessions AAC04895 CBB98487 EAW69520 EAW69521 EAW69522 EAW69523 EAW69524 EAW69525 Q14011 AB451225 BAG70039 AB451348 BAG70162 AF021336 AAC51787 AK094781 BAG52929 AK095781 AK128423 BAC87434 AK304185 BAG65065 AK304470 BAG65284 AK311601 AL133636 BC000403 AAH00403 BC000901 AAH00901 BI819825 BM706055 BP195090 BT007210 AAP35874 BU689520 CX785176 D78134 BAA11212 DA433715 DA695021 EU176219 ABW03670 EU176522 ABW03323 XM_006722637 XP_006722700 XM_011527668 XP_011525970 NM_001280 NP_001271 NM_001300815 NP_001287744 NM_001300829 NP_001287758 NR_023312 NR_023313
Function Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold- induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed. {ECO:0000250, ECO:0000269|PubMed:11574538, ECO:0000269|PubMed:16513844}.
Subcellular Location Nucleus, nucleoplasm {ECO:0000269|PubMed:11574538}. Cytoplasm {ECO:0000269|PubMed:11574538}. Note=Translocates from the nucleus to the cytoplasm after exposure to UV radiation. Translocates from the nucleus to the cytoplasm into stress granules upon various cytoplasmic stresses, such as osmotic and heat shocks. Its recruitment into stress granules occurs in the absence of TIAR proteins (By similarity). {ECO:0000250}.
Tissue Specificity Ubiquitous.

CIRBP Antibody - 13713 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from human thyroid, human liver, and SH-SY-5Y cells using CIRBP Antibody (upper) and β-Actin (D6A8) Rabbit mAb #8457 (lower).

CIRP (G-13) - sc-161012 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CIRP (G-13): sc-161012. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.

CIRP (Z-25) - sc-133460 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Rabbit
Clonality Polyclonal

Anti-CIRBP antibody - ab151589 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-CIRBP antibody (ab151589) at 1/1000 dilution + HCT116 whole cell lysate at 30 µg

Anti-CIRBP antibody - ab94999 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab94999 stained DU145 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab94999 at 5µg/ml overnight at +4°C. The secondary antibody (green) was DyLight® 488 goat anti- rabbit (ab96899) IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-CIRP / CIRBP Antibody (Internal) - LS-C345321 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of CIRBP Antibody with human HeLa Whole Cell lysate.

Anti-CIRP / CIRBP Antibody (aa81-91) - LS-C139617 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
CIRBP antibody (0.05 ug/ml) staining of Mouse Testis lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-CIRP / CIRBP Antibody - LS-C332788 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of HepG2 cell line, using CIRBP antibody.

Anti-CIRP / CIRBP Antibody - LS-C334809 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using CIRBP antibody.

Anti-CIRP / CIRBP Antibody - LS-C168784 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
CIRBP Antibody IHC of formalin-fixed and paraffin-embedded human lung carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-CIRP / CIRBP Antibody (aa161-172) IHC-plus™ - LS-B8341 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-CIRP / CIRBP antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8341 dilution 3.75 ug/ml.

Anti-CIRP / CIRBP Antibody (clone 1C9) IHC-plus™ - LS-B10519 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 1C9
Anti-CIRP / CIRBP antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10519 concentration 10 ug/ml.

Anti-CIRP / CIRBP Antibody (C-Terminus) IHC-plus™ - LS-B11497 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-CIRP / CIRBP Antibody (C-Terminus, AP) - LS-C254897 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CIRP / CIRBP Antibody (C-Terminus, Biotin) - LS-C254899 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CIRP / CIRBP Antibody (C-Terminus, APC) - LS-C254898 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CIRP / CIRBP Antibody (C-Terminus, FITC) - LS-C254900 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CIRP / CIRBP Antibody (C-Terminus, Azide-free, HRP) - LS-C254901 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CIRP / CIRBP Antibody - LS-C309916 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CIRP / CIRBP Antibody (C-Terminus, PE) - LS-C254902 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-CIRP / CIRBP Antibody (N-Terminus) - LS-C80316 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
HepG2 cell lysate. Antibody concentration: 0.5 ug/ml. Gel concentration: 15%.

Anti-CIRP / CIRBP Antibody (C-Terminus) - LS-C320402 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

CIRBP Antibody - NBP1-52067 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: CIRBP Antibody [NBP1-52067] - NBP1-52067 (0.01ug/ml) staining of Mouse Testis lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

CIRBP Antibody - NBP2-15905 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: CIRBP Antibody [NBP2-15905] - Sample (30 ug of whole cell lysate) A: HCT116 12% SDS PAGE gel, diluted at 1:1000.

CIRBP Antibody - NBP1-52066 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: CIRBP Antibody [NBP1-52066] - NBP1-52066 (0.05ug/ml) staining of Mouse Testis lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Search more