| Gene Symbol | CIRBP |
|---|---|
| Entrez Gene | 1153 |
| Alt Symbol | CIRP |
| Species | Human |
| Gene Type | protein-coding |
| Description | cold inducible RNA binding protein |
| Other Description | A18 hnRNP|cold inducible RNA-binding protein|cold-inducible RNA-binding protein|glycine-rich RNA binding protein |
| Swissprots | B3KT17 Q14011 B4E2X2 |
| Accessions | AAC04895 CBB98487 EAW69520 EAW69521 EAW69522 EAW69523 EAW69524 EAW69525 Q14011 AB451225 BAG70039 AB451348 BAG70162 AF021336 AAC51787 AK094781 BAG52929 AK095781 AK128423 BAC87434 AK304185 BAG65065 AK304470 BAG65284 AK311601 AL133636 BC000403 AAH00403 BC000901 AAH00901 BI819825 BM706055 BP195090 BT007210 AAP35874 BU689520 CX785176 D78134 BAA11212 DA433715 DA695021 EU176219 ABW03670 EU176522 ABW03323 XM_006722637 XP_006722700 XM_011527668 XP_011525970 NM_001280 NP_001271 NM_001300815 NP_001287744 NM_001300829 NP_001287758 NR_023312 NR_023313 |
| Function | Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold- induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed. {ECO:0000250, ECO:0000269|PubMed:11574538, ECO:0000269|PubMed:16513844}. |
| Subcellular Location | Nucleus, nucleoplasm {ECO:0000269|PubMed:11574538}. Cytoplasm {ECO:0000269|PubMed:11574538}. Note=Translocates from the nucleus to the cytoplasm after exposure to UV radiation. Translocates from the nucleus to the cytoplasm into stress granules upon various cytoplasmic stresses, such as osmotic and heat shocks. Its recruitment into stress granules occurs in the absence of TIAR proteins (By similarity). {ECO:0000250}. |
| Tissue Specificity | Ubiquitous. |