| Gene Symbol |
EID2
|
| Entrez Gene |
163126
|
| Alt Symbol |
CRI2, EID-2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
EP300 interacting inhibitor of differentiation 2
|
| Other Description |
CREBBP/EP300 inhibitor 2|CREBBP/EP300 inhibitory protein 2|E1A like inhibitor of differentiation 2|EID-1-like inhibitor of differentiation 2|EP300-interacting inhibitor of differentiation 2
|
| Swissprots |
Q6ZR61 Q6X7T0 A7YQ71 Q8N6I1
|
| Accessions |
EAW56909 Q8N6I1 AK128468 BAC87454 AY251272 AAP12559 BC030137 AAH30137 BC099899 AAH99899 NM_153232 NP_694964
|
| Function |
Interacts with EP300 and acts as a repressor of MYOD- dependent transcription and muscle differentiation. Inhibits EP300 histone acetyltransferase activity. Acts as a repressor of TGFB/SMAD transcriptional responses. May act as a repressor of the TGFB/SMAD3-dependent signaling by selectively blocking formation of TGFB-induced SMAD3-SMAD4 complex. {ECO:0000269|PubMed:12586827, ECO:0000269|PubMed:14585496, ECO:0000269|PubMed:14612439}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:14585496}.
|
| Tissue Specificity |
Most abundantly expressed in placenta. Highly expressed in liver, brain, heart, skeletal muscle, and kidney. {ECO:0000269|PubMed:14585496}.
|