Gene Symbol | EID2 |
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Entrez Gene | 163126 |
Alt Symbol | CRI2, EID-2 |
Species | Human |
Gene Type | protein-coding |
Description | EP300 interacting inhibitor of differentiation 2 |
Other Description | CREBBP/EP300 inhibitor 2|CREBBP/EP300 inhibitory protein 2|E1A like inhibitor of differentiation 2|EID-1-like inhibitor of differentiation 2|EP300-interacting inhibitor of differentiation 2 |
Swissprots | Q6ZR61 Q6X7T0 A7YQ71 Q8N6I1 |
Accessions | EAW56909 Q8N6I1 AK128468 BAC87454 AY251272 AAP12559 BC030137 AAH30137 BC099899 AAH99899 NM_153232 NP_694964 |
Function | Interacts with EP300 and acts as a repressor of MYOD- dependent transcription and muscle differentiation. Inhibits EP300 histone acetyltransferase activity. Acts as a repressor of TGFB/SMAD transcriptional responses. May act as a repressor of the TGFB/SMAD3-dependent signaling by selectively blocking formation of TGFB-induced SMAD3-SMAD4 complex. {ECO:0000269|PubMed:12586827, ECO:0000269|PubMed:14585496, ECO:0000269|PubMed:14612439}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:14585496}. |
Tissue Specificity | Most abundantly expressed in placenta. Highly expressed in liver, brain, heart, skeletal muscle, and kidney. {ECO:0000269|PubMed:14585496}. |
EID-2 CRISPR/Cas9 KO Plasmid (h) - sc-414857 from Santa Cruz Biotechnology
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EID-2 HDR Plasmid (h) - sc-414857-HDR from Santa Cruz Biotechnology
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EID-2 Double Nickase Plasmid (h) - sc-414857-NIC from Santa Cruz Biotechnology
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EID-2 Double Nickase Plasmid (h2) - sc-414857-NIC-2 from Santa Cruz Biotechnology
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EID-2 CRISPR Activation Plasmid (h) - sc-414857-ACT from Santa Cruz Biotechnology
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EID-2 CRISPR Activation Plasmid (h2) - sc-414857-ACT-2 from Santa Cruz Biotechnology
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EID-2 Lentiviral Activation Particles (h) - sc-414857-LAC from Santa Cruz Biotechnology
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EID-2 Lentiviral Activation Particles (h2) - sc-414857-LAC-2 from Santa Cruz Biotechnology
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EID-2 siRNA (h) - sc-97371 from Santa Cruz Biotechnology
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EID-2 shRNA Plasmid (h) - sc-97371-SH from Santa Cruz Biotechnology
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EID-2 shRNA (h) Lentiviral Particles - sc-97371-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU058631 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7732 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7732 from Sigma-Aldrich
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EID2 siRNA (Human) - CRJ5979 from Cohesion Biosciences
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EID2 - MBS8240933 from MyBioSource
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shRNA set against Human EID2 (NM_153232.3) - SHH284093 from Creative biogene
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shRNA set against Human EID2(NM_153232.3) - SHH028073 from Creative biogene
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EID2 shRNA Plasmid (Human) - CHJ5979 from Cohesion Biosciences
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EID2 miRNA 3'UTR clone - MiUTR1H-03149 from Creative biogene
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