| Gene Symbol |
MED27
|
| Entrez Gene |
9442
|
| Alt Symbol |
CRAP34, CRSP34, CRSP8, TRAP37
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mediator complex subunit 27
|
| Other Description |
CRSP complex subunit 8|cofactor required for Sp1 transcriptional activation, subunit 8, 34kDa|mediator of RNA polymerase II transcription subunit 27|p37 TRAP/SMCC/PC2 subunit|transcriptional coactivator CRSP34
|
| Swissprots |
Q5VTA5 Q9BU57 V9GYV9 Q4F964 O95401 Q9NYR4 Q6P2C8 Q5VTA4
|
| Accessions |
EAW87989 EAW87990 EAW87991 EAW87992 EAW87993 Q6P2C8 AF104252 AAD12721 AF230382 AAF37290 AI033804 AK022289 AK124232 AK298436 BAG60657 AK316345 BAH14716 BC002878 AAH02878 BC064608 AAH64608 BC070331 BP255072 BU069864 CD388680 DQ099387 AAZ13763 EU446747 ABZ92276 HG518166 CDI06889 Z36848 XM_005272236 XP_005272293 NM_001253881 NP_001240810 NM_001253882 NP_001240811 NM_004269 NP_004260
|
| Function |
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:10882111, ECO:0000269|PubMed:9989412}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:10882111, ECO:0000269|PubMed:9989412}.
|