| Gene Symbol |
NISCH
|
| Entrez Gene |
11188
|
| Alt Symbol |
I-1, IR1, IRAS, hIRAS
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nischarin
|
| Other Description |
I-1 receptor candidate protein|I1R candidate protein|imidazoline receptor 1|imidazoline receptor antisera selected
|
| Swissprots |
Q9Y2I1 Q7Z2X6 C9J245 Q9UFW3 Q9UEU4 Q6PIB4 Q6PGP3 Q9UES6 Q7L8M3
|
| Accessions |
EAW65228 EAW65229 EAW65230 EAW65231 Q9Y2I1 AB023192 BAA76819 AF058290 AAC33321 AF082516 AAC33104 AI889216 AK001505 AK027331 BAG51306 AK027428 BAG51321 AK075000 AK097732 AK291398 BAF84087 AK297657 BAG60023 AK302441 BAG63739 AK315001 AL117432 CAB55920 AL137405 AL703940 BC038102 AAH38102 BC050552 BC054494 AAH54494 BC056900 AAH56900 BU177208 DB496030 XM_005264839 XP_005264896 XM_006712955 XP_006713018 XM_011533317 XP_011531619 XM_011533318 XP_011531620 NM_001276293 NP_001263222 NM_001276294 NP_001263223 NM_007184 NP_009115
|
| Function |
Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension (By similarity). Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons (By similarity). Acts as a modulator of Rac-regulated signal transduction pathways (By similarity). Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity (By similarity). Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 pro
|
| Subcellular Location |
Cell membrane. Cytoplasm. Early endosome. Recycling endosome. Note=Enriched in the early/sorting and recycling endosomes. Colocalized in early/sorting endosomes with EEA1 and SNX2 and in recycling endosomes with transferrin receptor. Detected in the perinuclear region partially associated with punctate structures (By similarity). Colocalizes with PAK1 in cytoplasm, vesicular structures in the perinuclear area and membrane ruffles (By similarity). Colocalizes with RAC1 in the cytoplasm and vesicles structures (By similarity). Colocalized with MAPK1 and MAPK3 in RVLM neurons (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Isoform 1, isoform 3 and isoform 4 are expressed in brain. Isoform 1 is expressed in endocrine tissues. {ECO:0000269|PubMed:15028621, ECO:0000269|PubMed:9851558}.
|