NISCH

Gene Symbol	NISCH
Entrez Gene	11188
Alt Symbol	I-1, IR1, IRAS, hIRAS
Species	Human
Gene Type	protein-coding
Description	nischarin
Other Description	I-1 receptor candidate protein|I1R candidate protein|imidazoline receptor 1|imidazoline receptor antisera selected
Swissprots	Q9Y2I1 Q7Z2X6 C9J245 Q9UFW3 Q9UEU4 Q6PIB4 Q6PGP3 Q9UES6 Q7L8M3
Accessions	EAW65228 EAW65229 EAW65230 EAW65231 Q9Y2I1 AB023192 BAA76819 AF058290 AAC33321 AF082516 AAC33104 AI889216 AK001505 AK027331 BAG51306 AK027428 BAG51321 AK075000 AK097732 AK291398 BAF84087 AK297657 BAG60023 AK302441 BAG63739 AK315001 AL117432 CAB55920 AL137405 AL703940 BC038102 AAH38102 BC050552 BC054494 AAH54494 BC056900 AAH56900 BU177208 DB496030 XM_005264839 XP_005264896 XM_006712955 XP_006713018 XM_011533317 XP_011531619 XM_011533318 XP_011531620 NM_001276293 NP_001263222 NM_001276294 NP_001263223 NM_007184 NP_009115
Function	Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension (By similarity). Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons (By similarity). Acts as a modulator of Rac-regulated signal transduction pathways (By similarity). Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity (By similarity). Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 pro
Subcellular Location	Cell membrane. Cytoplasm. Early endosome. Recycling endosome. Note=Enriched in the early/sorting and recycling endosomes. Colocalized in early/sorting endosomes with EEA1 and SNX2 and in recycling endosomes with transferrin receptor. Detected in the perinuclear region partially associated with punctate structures (By similarity). Colocalizes with PAK1 in cytoplasm, vesicular structures in the perinuclear area and membrane ruffles (By similarity). Colocalizes with RAC1 in the cytoplasm and vesicles structures (By similarity). Colocalized with MAPK1 and MAPK3 in RVLM neurons (By similarity). {ECO:0000250}.
Tissue Specificity	Isoform 1, isoform 3 and isoform 4 are expressed in brain. Isoform 1 is expressed in endocrine tissues. {ECO:0000269|PubMed:15028621, ECO:0000269|PubMed:9851558}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

Recombinant Human NISCH Protein - H00011188-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Nischarin - H00011188-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Nischarin - H00011188-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

NISCH fusion protein - ag4880 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human NISCH, His-tagged - NISCH-27759TH from Creative Biomart Category Protein Source E. coli

Recombinant Nischarin (NISCH) - RPA249Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Nischarin (NISCH) - RPA249Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Nischarin (NISCH) - RPA249Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Nischarin(NISCH) ,partial - CSB-YP015821HU CSB-EP015821HU CSB-BP015821HU CSB-MP015821HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Nischarin - TP306026 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

NISCH Recombinant Protein Antigen - NBP1-81630PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Nischarin Protein (Recombinant) - abx166411 from Abbexa Category Protein Source Human Species Human

NISCH-Blocking-Peptide-N-Term - BP22144a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

NISCH Peptide, Human - M34GP10393H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Nischarin (NISCH) - RPU50482 from Biomatik Category Protein Prices $166.00, $288.00, $440.00, $550.40 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Human

NISCH Recombinant Protein (OPCD05670) - OPCD05670 from Aviva Systems Biology Category Protein Source E.coli Species Human

Nischarin (NISCH), partial, Recombinant Protein - MBS1344223 from MyBioSource Category Protein Prices $995.00, $995.00, $1,220.00, $1,220.00, $1,460.00, $1,460.00, $1,915.00, $1,915.00, $1,950.00, $2,870.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 50 µg (Mammalian-Cell), 500 µg (Yeast), 1 mg (E-Coli), 100 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast), 500 µg (Baculovirus), 1 mg (Baculovirus) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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