| Gene Symbol |
PLXNB3
|
| Entrez Gene |
5365
|
| Alt Symbol |
PLEXB3, PLEXR, PLXN6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
plexin B3
|
| Other Description |
plexin 6|plexin-B3
|
| Swissprots |
Q9HDA4 Q9ULL4 F5H773 B7Z3E6
|
| Accessions |
EAW72815 Q9ULL4 AB033032 BAA86520 AF149019 AAG01376 AK292535 BAF85224 AK295762 BAH12182 AK295849 BAH12202 AK295894 BAH12215 AK296538 BAH12382 AK304705 BAH14241 AK307894 AY927551 BC172435 AAI72435 NM_001163257 NP_001156729 NM_005393 NP_005384
|
| Function |
Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. {ECO:0000269|PubMed:15218527, ECO:0000269|PubMed:20696765, ECO:0000269|PubMed:21706053}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:15218527, ECO:0000269|PubMed:16122393}; Single-pass type I membrane protein {ECO:0000269|PubMed:15218527, ECO:0000269|PubMed:16122393}. Note=Colocalizes with RIT2/RIN at the plasma membrane.
|
| Tissue Specificity |
Expression detected in Purkinje and granular cells in cerebellum, and in brain neocortex but not in corpus callosum. Expressed in glioma cells and embryonic kidney cells (at protein level). Expressed in brain, liver, pancreas and placenta, with weak expression detected also in lung and kidney. Expressed in several glioma cell lines. {ECO:0000269|PubMed:16122393, ECO:0000269|PubMed:20696765, ECO:0000269|PubMed:21706053}.
|
| Top Pathways |
Axon guidance
|