PLXNB3
| Gene Symbol | PLXNB3 |
|---|---|
| Entrez Gene | 5365 |
| Alt Symbol | PLEXB3, PLEXR, PLXN6 |
| Species | Human |
| Gene Type | protein-coding |
| Description | plexin B3 |
| Other Description | plexin 6|plexin-B3 |
| Swissprots | Q9HDA4 Q9ULL4 F5H773 B7Z3E6 |
| Accessions | EAW72815 Q9ULL4 AB033032 BAA86520 AF149019 AAG01376 AK292535 BAF85224 AK295762 BAH12182 AK295849 BAH12202 AK295894 BAH12215 AK296538 BAH12382 AK304705 BAH14241 AK307894 AY927551 BC172435 AAI72435 NM_001163257 NP_001156729 NM_005393 NP_005384 |
| Function | Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. {ECO:0000269|PubMed:15218527, ECO:0000269|PubMed:20696765, ECO:0000269|PubMed:21706053}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:15218527, ECO:0000269|PubMed:16122393}; Single-pass type I membrane protein {ECO:0000269|PubMed:15218527, ECO:0000269|PubMed:16122393}. Note=Colocalizes with RIT2/RIN at the plasma membrane. |
| Tissue Specificity | Expression detected in Purkinje and granular cells in cerebellum, and in brain neocortex but not in corpus callosum. Expressed in glioma cells and embryonic kidney cells (at protein level). Expressed in brain, liver, pancreas and placenta, with weak expression detected also in lung and kidney. Expressed in several glioma cell lines. {ECO:0000269|PubMed:16122393, ECO:0000269|PubMed:20696765, ECO:0000269|PubMed:21706053}. |
| Top Pathways | Axon guidance |
plexin-B3 CRISPR/Cas9 KO Plasmid (h) - sc-405160 from Santa Cruz Biotechnology
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plexin-B3 HDR Plasmid (h) - sc-405160-HDR from Santa Cruz Biotechnology
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plexin-B3 Double Nickase Plasmid (h) - sc-405160-NIC from Santa Cruz Biotechnology
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plexin-B3 Double Nickase Plasmid (h2) - sc-405160-NIC-2 from Santa Cruz Biotechnology
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plexin-B3 CRISPR Activation Plasmid (h) - sc-405160-ACT from Santa Cruz Biotechnology
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plexin-B3 CRISPR Activation Plasmid (h2) - sc-405160-ACT-2 from Santa Cruz Biotechnology
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plexin-B3 Lentiviral Activation Particles (h) - sc-405160-LAC from Santa Cruz Biotechnology
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plexin-B3 Lentiviral Activation Particles (h2) - sc-405160-LAC-2 from Santa Cruz Biotechnology
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plexin-B3 siRNA (h) - sc-45581 from Santa Cruz Biotechnology
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plexin-B3 shRNA Plasmid (h) - sc-45581-SH from Santa Cruz Biotechnology
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plexin-B3 shRNA (h) Lentiviral Particles - sc-45581-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU101371 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17015 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17015 from Sigma-Aldrich
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PLXNB3 siRNA (Human) - CRH3602 from Cohesion Biosciences
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Plexin B3 RNAi - H00005365-R02 from Novus Biologicals
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shRNA set against Human PLXNB3 (NM_005393.2) - SHH378260 from Creative biogene
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Human PLXNB3 siRNA - orb264104 from Biorbyt
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PLXNB3 shRNA Plasmid (Human) - CHH3602 from Cohesion Biosciences
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PLXNB3 miRNA 3'UTR clone - MiUTR3H-02643 from Creative biogene
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PLXNB3 miRNA 3'UTR clone - MiUTR3H-02644 from Creative biogene
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