PLXNB3

Gene Symbol	PLXNB3
Entrez Gene	5365
Alt Symbol	PLEXB3, PLEXR, PLXN6
Species	Human
Gene Type	protein-coding
Description	plexin B3
Other Description	plexin 6|plexin-B3
Swissprots	Q9HDA4 Q9ULL4 F5H773 B7Z3E6
Accessions	EAW72815 Q9ULL4 AB033032 BAA86520 AF149019 AAG01376 AK292535 BAF85224 AK295762 BAH12182 AK295849 BAH12202 AK295894 BAH12215 AK296538 BAH12382 AK304705 BAH14241 AK307894 AY927551 BC172435 AAI72435 NM_001163257 NP_001156729 NM_005393 NP_005384
Function	Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. {ECO:0000269|PubMed:15218527, ECO:0000269|PubMed:20696765, ECO:0000269|PubMed:21706053}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:15218527, ECO:0000269|PubMed:16122393}; Single-pass type I membrane protein {ECO:0000269|PubMed:15218527, ECO:0000269|PubMed:16122393}. Note=Colocalizes with RIT2/RIN at the plasma membrane.
Tissue Specificity	Expression detected in Purkinje and granular cells in cerebellum, and in brain neocortex but not in corpus callosum. Expressed in glioma cells and embryonic kidney cells (at protein level). Expressed in brain, liver, pancreas and placenta, with weak expression detected also in lung and kidney. Expressed in several glioma cell lines. {ECO:0000269|PubMed:16122393, ECO:0000269|PubMed:20696765, ECO:0000269|PubMed:21706053}.
Top Pathways	Axon guidance

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

plexin-B3 (C-12) - sc-46240 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

plexin-B3 (H-90) - sc-67144 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

plexin-B3 (K-12) - sc-46241 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Plexin-B3 (N-12) - sc-46242 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

plexin-B3 (N-19) - sc-46243 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-PLXNB3 antibody - ab135302 from Abcam Prices $359.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PLXNB3 / Plexin B3 Antibody (aa985-1034) - LS-C151964 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-PLXNB3 / Plexin B3 Antibody - LS-C150230 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Sheep Clonality Polyclonal

Plexin B3 Antibody [Unconjugated] - AF4958 from Novus Biologicals Prices $99.00, $329.00 Sizes 25 µg, 100 µg Host Sheep Clonality Polyclonal

Plexin B3 Antibody (905805) - FAB4958A-025 from Novus Biologicals Host Mouse Clonality Monoclonal Clone 905805

Plexin B3 Antibody - NBP2-38573 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Plexin B3 Antibody [Biotin] - BAF4958 from Novus Biologicals Prices $390.00 Sizes 50 µg Host Sheep Clonality Polyclonal

Plexin B3 Polyclonal Antibody - bs-11470R from Bioss Prices $269.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Plexin B3 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-11470R-A350 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Plexin B3 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-11470R-A488 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Plexin B3 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-11470R-A555 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Plexin B3 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-11470R-A647 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Plexin B3 Polyclonal Antibody, Cy3 Conjugated - bs-11470R-Cy3 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Plexin B3 Polyclonal Antibody, Cy5 Conjugated - bs-11470R-Cy5 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Plexin B3 Polyclonal Antibody, Cy5.5 Conjugated - bs-11470R-Cy5.5 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Plexin B3 Polyclonal Antibody, Cy7 Conjugated - bs-11470R-Cy7 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Plexin B3 Polyclonal Antibody, FITC Conjugated - bs-11470R-FITC from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Rabbit Anti-Plexin B3 Polyclonal Antibody, PE Conjugated - bs-11470R-PE from Bioss Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Plexin B3 Polyclonal Antibody, Biotin Conjugated - bs-11470R-Biotin from Bioss Prices $349.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Plexin B3 Polyclonal Antibody, HRP Conjugated - bs-11470R-HRP from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

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