| Gene Symbol |
CITED4
|
| Entrez Gene |
163732
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4
|
| Other Description |
MRG-2|MSG1-related protein 2|cbp/p300-interacting transactivator 4|transcriptional co-activator 4
|
| Swissprots |
Q96RK1
|
| Accessions |
AAK64235 AAL73989 CAN89457 CAN89458 CAP11404 CAP11405 EAX07195 Q96RK1 BC035496 AAH35496 BC052559 AAH52559 NM_133467 NP_597724
|
| Function |
Acts as transcriptional coactivator for TFAP2/AP-2. Enhances estrogen-dependent transactivation mediated by estrogen receptors. May function as an inhibitor of transactivation by HIF1A by disrupting HIF1A interaction with CREBBP. May be involved in regulation of gene expression during development and differentiation of blood cells, endothelial cells and mammary epithelial cells. {ECO:0000269|PubMed:11744733, ECO:0000269|PubMed:15342390}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:11744733, ECO:0000269|PubMed:15342390}. Cytoplasm {ECO:0000269|PubMed:11744733, ECO:0000269|PubMed:15342390}.
|
| Tissue Specificity |
Expressed in most tissues examined with highest levels of expression in heart, liver, skeletal muscle and pancreas. Also expressed in bladder cell line ECV-304 and in various breast cancer cell lines. Also detected in both in situ and invasive breast tumors where its expression is down-regulated and mostly restricted to the cytoplasm of malignant epithelium. Down-regulation of expression is associated with elevated levels of HIF1A and increased tumor growth and angiogenesis. {ECO:0000269|PubMed:11744733, ECO:0000269|PubMed:15342390}.
|